Verbal memory and 5-HT1A receptors in healthy volunteers--A PET study with [carbonyl-(11)C]WAY-100635

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Jani PenttiläJarmo Hietala

Abstract

The serotonin 5-HT1A receptor is a putative drug development target in disorders with cognitive and in particular memory deficits. However, previous human positron emission tomography (PET) studies on 5-HT1A receptor binding and memory functions have yielded discrepant results. We explored the association between verbal memory and 5-HT1A receptor binding in 24 healthy subjects (14 male, 10 female, aged 18-41 years). The cognitive tests included the Wechsler Memory Scale-Revised (WMS-R), Wechsler Adult Intelligence Scale-Revised (WAIS-R) and Wisconsin Card Sorting Test (WCST). 5-HT1A receptor binding was measured with PET and the radioligand [carbonyl-(11)C]WAY-100635, which was quantified with the gold standard method based on kinetic modeling using arterial blood samples. We found that global 5-HT1A receptor binding was positively correlated with measures of verbal memory, such that subjects who had higher receptor binding tended to have better verbal memory than subjects who had lower receptor binding. Regional analyses suggested significant correlations in multiple neocortical brain regions and the raphe nuclei. We did not find significant correlations between 5-HT1A receptor binding and executive functions as measured with ...Continue Reading

References

Feb 19, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·W J RiedelH M van Praag
Feb 4, 2003·The American Journal of Psychiatry·Fumihiko YasunoKazutoshi Suzuki
Feb 18, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ramin V ParseyJ John Mann
May 11, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jussi HirvonenJarmo Hietala
Jul 18, 2006·Current Pharmaceutical Design·J A J SchmittW J Riedel
May 24, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Robert B InnisRichard E Carson
Sep 7, 2007·Brain Research·Ilkka K MartikainenAntti Pertovaara
Jan 8, 2009·The International Journal of Neuropsychopharmacology·Jacqueline BorgLars Farde
May 12, 2009·Neuroscience and Biobehavioral Reviews·Daniel MendelsohnAnke Sambeth
Mar 2, 2010·NeuroImage·Ville LummeJarmo Hietala
Nov 5, 2011·Epilepsia·William H TheodoreSusumu Sato
Mar 29, 2012·European Archives of Psychiatry and Clinical Neuroscience·David ZillesOliver Gruber
Sep 5, 2015·Psychiatry Research·Jussi HirvonenJarmo Hietala

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Citations

Apr 25, 2016·Biological Psychiatry·Sofi da Cunha-BangGitte Moos Knudsen
Mar 28, 2017·Reviews in the Neurosciences·Alfredo Meneses
Nov 11, 2020·Neuroscience and Biobehavioral Reviews·Salar VaseghiMohammad-Reza Zarrindast

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