Vergence-mediated modulation of the human horizontal vestibulo-ocular reflex is eliminated by a partial peripheral gentamicin lesion

Experimental Brain Research
Americo A MigliaccioJohn P Carey

Abstract

The angular vestibulo-ocular reflex normally has an increased response during vergence on a near target. Surgical unilateral vestibular deafferentation reduces the horizontal vestibulo-ocular reflex (VOR) in response to far target viewing and eliminates this vergence effect. Intratympanic gentamicin treatment reduces VOR gain during far viewing, but the reduction is less severe than that after unilateral vestibular deafferentation. We sought to determine how gentamicin would affect vergence-mediated modulation of the VOR. The VOR in response to passive head impulses in the horizontal plane while viewing a far (124 cm) or near (15 cm) target was evaluated in 11 subjects following intratympanic gentamicin treatment. Three of these subjects had also been tested immediately prior to receiving gentamicin. The impulses were low amplitude (approximately 20 degrees ), high velocity (approximately 150 degrees /s), high acceleration (approximately 3,000 degrees /s2) horizontal head rotations administered manually by the investigator. Binocular eye and head velocity were recorded using the scleral search coil technique. The VOR gain was defined as eye velocity divided by inverted head velocity. Prior to intratympanic gentamicin, the VOR g...Continue Reading

Citations

Jan 12, 2008·Experimental Brain Research·Americo A MigliaccioJohn P Carey
Jul 16, 2013·Experimental Brain Research·Daniel ChimAmerico A Migliaccio
Jul 1, 2006·Journal of the Association for Research in Otolaryngology : JARO·Michael C SchubertCharles C Della Santina
Nov 28, 2012·Journal of the Association for Research in Otolaryngology : JARO·Americo A Migliaccio, Michael C Schubert
Jan 9, 2013·Journal of the Association for Research in Otolaryngology : JARO·Patrick P HübnerAmerico A Migliaccio
Sep 28, 2007·Journal of the Association for Research in Otolaryngology : JARO·Sofia Lyford-PikeJohn P Carey
Feb 26, 2008·Archives of Physical Medicine and Rehabilitation·Michael C SchubertJohn P Carey
Mar 4, 2021·Experimental Brain Research·László T TamásBéla Büki

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