Verification and Implementation of HIV Antibody Differentiation Testing to Improve Turnaround Time for the HIV Diagnostic Algorithm.

Laboratory Medicine
Allison B Chambliss, Ira A Shulman

Abstract

Relying on reference laboratories for HIV confirmation testing may lead to delays in treatment and can cause stress for patients who have positive HIV screening results. To internalize HIV-1/HIV-2 antibody differentiation testing within the hospital laboratory. We analytically verified an HIV antibody differentiation immunoassay and subsequently compared result turnaround times (TATs) for HIV antibody differentiation and HIV-1 qualitative RNA in the months before and after the test internalization. HIV antibody differentiation was successfully verified. TATs for HIV antibody differentiation and HIV-1 RNA significantly improved, from medians of 40.4 hours and 156.5 hours to medians of 17.7 hours and 56.5 hours, respectively, after the internalization. The 90th-percentile turnaround times declined by 72% and 44%, respectively. It is feasible for a hospital laboratory to verify HIV antibody-differentiation testing. Its implementation may considerably improve result TATs for the HIV diagnostic algorithm.

References

Dec 18, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·L MallochJ Kim
Jul 13, 2016·JAMA : the Journal of the American Medical Association·Huldrych F GünthardPaul A Volberding
Aug 23, 2018·Obstetrics and Gynecology·UNKNOWN Committee on Obstetric Practice, UNKNOWN HIV Expert Work Group
Dec 31, 2018·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Wei LuoSilvina Masciotra

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