Verification of 20 Mathematical Formulas for Discriminating Between Iron Deficiency Anemia and Thalassemia Trait in Microcytic Anemia.

Laboratory Medicine
Johannes J M L Hoffmann, Eloísa Urrechaga

Abstract

Currently, more than 45 mathematical formulas based on simple red blood cell (RBC) parameters have been proposed for differentiating between iron deficiency and thalassemia in microcytic anemia, of which 20 are relatively new and have not been thoroughly independently verified. The study goal was to verify these 20 new formulas and to identify which RBC parameters have a decisive impact on the performance of those formulas. A database containing laboratory and diagnostic data from 2788 subject individuals with microcytic anemia was used for assessing performance by receiver operating characteristic (ROC) analysis. The new Index26 had excellent performance, equivalent to the Green and King, Jayabose, and Janel formulas previously identified in the literature. The discriminant power of nearly all newer formulas was lower in our study than that claimed by the original authors. We discovered that a well-performing formula requires mean cell volume (MCV), RBC distribution width (RDW), and RBC measurements, whereas hemoglobin measurements appeared not to be essential. Only the new Index26 performed at a level comparable to the very strongest established formulas. All other new formulas had lower performance than was claimed in the or...Continue Reading

References

Jul 8, 2009·Pakistan Journal of Biological Sciences : PJBS·M A EhsaniA Rashidi
Nov 5, 2015·Clinical Chemistry and Laboratory Medicine : CCLM·Johannes J M L HoffmannUrko Aguirre
Aug 16, 2016·Revista brasileira de hematologia e hemoterapia·Januária F MatosMaria das G Carvalho
Feb 10, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Eloísa Urrechaga, Johannes J M L Hoffmann
Mar 16, 2017·Mediterranean Journal of Hematology and Infectious Diseases·Vincenzo De SanctisMichael Angastiniotis
Aug 24, 2017·Revista brasileira de hematologia e hemoterapia·Johannes J M L Hoffmann, Eloísa Urrechaga
Jan 13, 2018·Mediterranean Journal of Hematology and Infectious Diseases·Idit Lachover RothAriel Koren
Jun 22, 2019·International Journal of Laboratory Hematology·Johannes J M L Hoffmann, Eloísa Urrechaga

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Citations

Jun 13, 2020·Scandinavian Journal of Clinical and Laboratory Investigation·Johannes J M L Hoffmann, Eloísa Urrechaga
Oct 26, 2021·British Journal of Haematology·Deborah Rund

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