PMID: 9185909Jun 1, 1997Paper

Verocay body--prominent cutaneous schwannoma

The American Journal of Dermatopathology
B ZelgerB Zelger

Abstract

We report on eight cases of a distinct variant of cutaneous schwannoma characterized by prominent Verocay body formation (75-100% of the tumor bulk) that may cause considerable diagnostic difficulties. Like ordinary cutaneous schwannomas, these lesions preferred the head and neck region of young adults without sexual predilection and were clinically interpreted as cyst, basal cell carcinoma, or nevus. Histological examination revealed well-circumscribed nodules. Three of them consisted exclusively of nodular or ribbon-like Verocay bodies. A variable admixture of Antoni A or B type of differentiation (< 25%) was seen in five other cases. The following patterns were seen: fascicular spindle-shaped, onion-like epithelioid, myxoid-hypocellular, and degenerated ("ancient") with prominent fibrosis/hyalinosis and occasional bizarre giant cells. Immunohistochemically, the lesions were positive for S-100 protein (and vimentin) but negative for a broad panel of neurogenic and intermediate filament markers. The capsule showed focal labeling for EMA and--when it was markedly thickened--also for SMA. Labeling with E9, an anti-metallothionein marker indicative of cell activity, was negative, underscoring the slow growth potential of these le...Continue Reading

References

May 1, 1989·The American Journal of Surgical Pathology·S W WeissG L Bratthauer
Dec 1, 1986·Journal of Cutaneous Pathology·V S Schwob, D J Santa Cruz
Apr 17, 1986·The New England Journal of Medicine·S A SørensenA Nielsen
Oct 1, 1983·The American Journal of Surgical Pathology·J M WoodruffR A Erlandson
Jun 1, 1995·Histopathology·B W ZelgerB G Zelger
Jul 1, 1994·The American Journal of Surgical Pathology·B ZelgerK W Schmid
Mar 1, 1994·The American Journal of Surgical Pathology·J R GoldblumS W Weiss
Oct 1, 1960·Neurology·S A LUSE

❮ Previous
Next ❯

Citations

Nov 23, 2006·Acta Neuropathologica·Fausto J RodriguezRobert A Erlandson
Sep 28, 2000·Micron : the International Research and Review Journal for Microscopy·B Eyden, M Tzaphlidou
Feb 23, 1999·The American Journal of Dermatopathology·P J Lespi, R Smit
Jul 23, 2011·The American Journal of Dermatopathology·Asok BiswasJag Bhawan
Nov 20, 2013·Indian Journal of Dermatology·Chinmay HalderSanchaita Bala
May 7, 2002·The Journal of Dermatology·Mi Woo LeeJai-Kyoung Koh
Nov 4, 2008·Journal of Cutaneous Pathology·Amir MohammadiRonald Rhatigan
Apr 27, 2005·Journal of the Neurological Sciences·Yan WangNobuya Inagaki
Jul 20, 1999·Dermatologic Clinics·A R Hudson, B R Smoller
Sep 19, 2006·Clinical Orthopaedics and Related Research·Scott J EllisCarol D Morris
Apr 20, 2013·The American Journal of Surgical Pathology·Luis RequenaHeinz Kutzner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.