Verrucous carcinoma of the endometrium: case history, pathologic findings, brief review of literature and discussion

Gynecologic Oncology
Diego IllanesPatrick Timmins

Abstract

Verrucous carcinoma is a rare condition. A defined disease of the oral cavity, larynx, esophagus, skin, vulva, vagina and cervix. But a verrucous carcinoma arising from the endometrium without evidence of cervical malignancy or endometrial adenocarcinoma is extremely rare. A 67-year-old G2P2 menopausal patient that was referred for consultation 1 year after presenting with vaginal bleeding to her gynecologist who subsequently underwent several endometrial biopsies where the pathological findings were repetitively similar: papillary squamous proliferation, cytologically bland with low mitotic activity but extensive proliferation. A hysterectomy with bilateral salpingo-oophorectomy was performed. The final histologic examination revealed a squamous cell carcinoma of endometrium, verrucous and well differentiated, and there was no cervical invasion identified. This is a rare form of endometrial cancer with apparent favorable prognosis that must be considered when squamous cells are identified on endometrial samplings.

References

Aug 10, 2000·The Journal of Obstetrics and Gynaecology Research·Y ShidaraT Tanaka

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Citations

May 24, 2008·Clinical Oncology : a Journal of the Royal College of Radiologists·L Brown
Apr 17, 2007·Journal of the American Academy of Dermatology·Arjen F NikkelsGérald E Piérard
Jan 22, 2008·International Journal of Surgical Pathology·Tiffany T FancherJ Alexander Palesty

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