PMID: 15229749Jul 2, 2004Paper

Verrucous carcinoma of the esophagus eluding multiple sets of endoscopic biopsies and endoscopic ultrasound: a case report and review of the literature

Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie
Shane DevlinJoseph Romagnuolo

Abstract

A 56-year-old woman was noted to have a 5 cm to 6 cm long, irregular narrowing of the distal esophagus on an upper gastrointestinal series. Initial endoscopy revealed a polypoid mass in the distal esophagus and concurrent endoscopic ultrasound revealed changes typical of inflammation but no evidence of an obvious neoplastic process. Repeated biopsies revealed only inflammation with no evidence of malignancy. Only after prolonged acid suppression did biopsies reveal verrucous carcinoma of the esophagus. The patient underwent a trans-hiatal esophagectomy and has remained well with no evidence of progression since. Verrucous carcinoma is a rare variant of squamous cell carcinoma, taking on a papillary or warty appearance grossly. Histological diagnosis may be difficult because this tumour typically shows no high-grade dysplasia. Therefore, diagnosis can be challenging, often requiring multiple sets of endoscopic biopsies due to the overlying hyperkeratotic layer. Of the 20 cases that have been reported, this is the second to provide an endosonographic description and the first to describe a change in endoscopic appearance with acid suppression.

Citations

Jan 26, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Derrick ChenXiuli Liu
Aug 2, 2013·European Journal of Gastroenterology & Hepatology·Zaida Adrián-de-GanzoEnrique Quintero
Jan 7, 2016·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·André BrandaliseNelson Ary Brandalise
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Oct 17, 2012·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·S SweetserL M Wong Kee Song
Oct 28, 2016·Annals of the New York Academy of Sciences·Monika Tripathi, Paul E Swanson
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Feb 8, 2020·Surgical Case Reports·Satoshi TabuchiShigeyuki Kawachi
Oct 10, 2020·Zeitschrift für Gastroenterologie·Thomas FrielingBernhard Hemmerlein
Nov 14, 2018·Human Pathology·Rocco CappellessoMassimo Rugge
Apr 10, 2020·Archives of Pathology & Laboratory Medicine·Deepika SavantZhaohai Yang
Mar 6, 2017·Gastroenterology·Sukhman ShergillSeth Sweetser

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