PMID: 16512487Mar 4, 2006Paper

Verrucous carcinoma versus papillary squamous cell carcinoma of the larynx 9 cases report

Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
Jiqun WangYanchun Shan

Abstract

To investigate the clinical, pathological character and differential diagnosis between verrucous carcinoma (VC) and papillary squamous cell carcinoma (PSCC) of the larynx. Four cases of VC and five cases of PSCC of larynx in our hospital between 1991 approximately 2003 were studied retrospectively, the clinical and pathology character of VC and PSCC were observed. Highly differentiated squamous cell and epithelial pearls or keratinized matter can be seen in the four cases of VC. Invasion of the basement membrane is often nonetheless, moderate to serve inflammatory reaction usually exist in the stroma adjacent to the advancing margin, no cervical lymph node metastases, no local recurrence and the prognosis is excellent. Exophytic malignant proliferation of the squamous cell with fibrovascular core can be seen in all the cases of PSCC, cell pathology is similar to the conventional SCC but no cervical metastases were observed and the prognosis is better than the conventional SCC. The external appearance of VC and PSCC is similar, but there are discrepancy in the cellular differentiation and the atypia of the tumor cells, stroma inflammatory reaction, recurrence, regional metastases, treatment, prognosis. Accurate differential diag...Continue Reading

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