Verrucous cell carcinoma arising from an underlying giant keratoacanthoma

The International Journal of Lower Extremity Wounds
Manish BansalShyam Sunder Pandey

Abstract

Keratoacanthoma is a well-known, fast-growing, benign squamous epithelial neoplasm that usually presents as a solitary, dome-shaped, pink or flesh-colored nodule developing a central keratin-filled crater. Few authors consider it to be a benign cutaneous tumor whereas others suggest that it should be regarded as a low-grade variant of cutaneous squamous cell carcinoma (SCC). A 21-year-old female presented with a firm, nontender, well-defined plaque with irregular margins measuring about 8 × 4 cm over the dorsal aspect of the right foot along with an exuberant growth from the plaque measuring 4 × 5cm. There was no lymphadenopathy. Systemic examination was within normal limits. Routine investigations, including complete blood counts, liver and renal function tests, urinalysis, chest radiographs, and abdominal ultrasonography, were normal. Histopathological examination of a skin biopsy from the plaque showed features suggestive of keratoacanthoma, whereas exuberant growth overlying the plaque showed features of verrucous carcinoma (a variant of SCC). Thus, it represents a case of SCC arising from a giant keratoacanthoma.

References

Aug 1, 1979·Annals of Plastic Surgery·K PickrellH Neale
Apr 1, 1969·Indian Journal of Dermatology·K D Lahiri
Jan 1, 1994·Journal of the American Academy of Dermatology·R A Schwartz
May 27, 2006·The Journal of Investigative Dermatology·Ole Petter F ClausenPaula M Deangelis

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Citations

Jun 15, 2021·Cancer Treatment and Research Communications·Valerie van DamLambert Julien

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Methods Mentioned

BETA
chromosomal aberration
biopsy

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Carcinoma, Squamous Cell

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