Versatile Electrochemical Sensing Platform for Bacteria

Analytical Chemistry
Sabine KussRichard G Compton

Abstract

Bacterial infections present one of the leading causes of mortality worldwide, resulting in an urgent need for sensitive, selective, cost-efficient, and easy-to-handle technologies to rapidly detect contaminations and infections with pathogens. The presented research reports a fully functional chemical-detection principle, addressing all of the above-mentioned requirements for a successful biosensing device. With the examples of Escherichia coli and Neisseria gonorrheae, we present an electrochemical biosensor based on the bacterial expression of cytochrome c oxidase for the selective detection of clinically relevant concentrations within seconds after pathogen immobilization. The generality of the biochemical reaction, as well as the easy substitution of target-specific antibodies make this concept applicable to a large number of different pathogenic bacteria. The successful transfer of this semidirect detection principle onto inexpensive, screen-printed electrodes for portable devices represents a potential major advance in the field of biosensor development.

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Citations

Oct 12, 2019·The Analyst·Olja Simoska, Keith J Stevenson
Nov 5, 2019·Chemistry : a European Journal·Kaisong YuanAlberto Escarpa
Feb 15, 2020·Nature Reviews. Microbiology·Alex van BelkumWilliam Michael Dunne
Oct 7, 2020·The Analyst·Cristina Adrover-JaumeRoberto de la Rica
Oct 6, 2020·SLAS Technology·Veronica R CampbellDaniel T Kamei
May 7, 2021·ACS Sensors·Lauren M CastleAriel L Furst
Dec 9, 2021·Analytical Methods : Advancing Methods and Applications·Xuyao WangJian Liu

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