Versatile in situ synthesis of MnO2 nanolayers on upconversion nanoparticles and their application in activatable fluorescence and MRI imaging

Chemical Science
Yuan WuWeihong Tan

Abstract

We have developed a simple and versatile strategy for in situ growth of MnO2 on the surfaces of oleic acid-capped hydrophobic upconversion nanoparticles (UCNPs) by optimizing the component concentrations in the Lemieux-von Rudloff reagent. The oxidation time was shortened by a factor of two compared to that of the reported method. This oxidation process has no obvious adverse effects on the phases of UCNPs. STEM, X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR) and energy-dispersive X-ray analysis (EDX) characterization demonstrated the successful growth of MnO2 on the surfaces of UCNPs. Furthermore, when the weight ratio of MnO2/UCNPs reached (147.61 ± 17.63) μg mg-1, 50% of the initial upconversion luminescence of UCNPs was quenched, as revealed by fluorescence and inductively coupled plasma optical emission spectrometry (ICP-OES) results. The presence of the surface MnO2 precipitate not only confers high dispersity of UCNPs in water, but also allows further activatable magnetic resonance imaging (MRI) and fluorescence multimodal imaging after reduction to Mn2+ by intracellular glutathione (GSH). A novel targeted drug carrier nanosystem was prepared to protect MnO2 from early decomposition in blood ci...Continue Reading

References

Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·J W BulteJ A Frank
Dec 3, 2002·Science·Benoit DubertretAlbert Libchaber
Mar 20, 2003·Journal of the American Chemical Society·Yoshitomo OmomoMamoru Watanabe
Jan 6, 2004·Nature Biotechnology·Diane S LidkeThomas M Jovin
Nov 30, 2004·Nature Materials·Jongnam ParkTaeghwan Hyeon
Oct 26, 2005·Nature Biotechnology·Ralph WeisslederLee Josephson
Dec 17, 2005·Chemical Communications : Chem Comm·Min XieDai-Wen Pang
Jul 29, 2006·Proceedings of the National Academy of Sciences of the United States of America·Dihua ShangguanWeihong Tan
Feb 19, 2008·Journal of the American Chemical Society·Zhigang ChenChunhui Huang
Jul 8, 2008·Molecular Aspects of Medicine·Shelly C Lu
Sep 16, 2008·International Journal of Pharmaceutics·Babita GaihreHak Yong Kim
Oct 20, 2011·Chemical Society Reviews·Jing ZhouFuyou Li
Nov 24, 2011·Journal of the American Chemical Society·Renren DengXiaogang Liu
Apr 7, 2012·Chemical Society Reviews·Miriam ColomboWolfgang J Parak
Jun 22, 2013·Chemical Society Reviews·Juan GalloEric O Aboagye
Aug 21, 2013·Journal of the American Chemical Society·Xiaoji XieXiaogang Liu
Oct 1, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Zhen ZouQuan Zhou
Jul 26, 2014·Journal of the American Chemical Society·Zilong ZhaoWeihong Tan
Apr 29, 2015·Chemical Society Reviews·Serena Silvi, Alberto Credi
Jun 20, 2015·Chemical Society Reviews·L ProdiN Zaccheroni
Mar 19, 2016·Journal of Integrative Medicine·Jesmin MondalAnisur Rahman Khuda-Bukhsh
Sep 11, 2016·Advanced Drug Delivery Reviews·Chensu WangJinming Gao

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Citations

Apr 5, 2019·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Wanni WangHaisheng Qian
Jun 5, 2020·Chemical Communications : Chem Comm·Jia WenShiguo Sun
Jul 22, 2020·Advanced Healthcare Materials·Zachary T RosenkransWeibo Cai
Jan 26, 2020·Archives of Pharmacal Research·Xuan Thien Le, Yu Seok Youn
Feb 7, 2019·Advanced Healthcare Materials·JingJing ZhangYi Lu
Nov 19, 2020·The Analyst·Riikka PeltomaaMaría C Moreno-Bondi
Feb 18, 2021·ACS Applied Materials & Interfaces·Sitao XieWeihong Tan
Mar 20, 2020·ACS Applied Materials & Interfaces·Xiaoqian JiangHua Kuang
Sep 28, 2018·Analytical Chemistry·Zhiming ZhangYong Zhang
Sep 24, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yunkai KouXiuwen Zheng

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Methods Mentioned

BETA
X-ray
transmission electron microscopy
Fluorescence
fluorescence imaging
electrophoresis
flow cytometry
Confocal microscopy

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