Versatile nitro-fluorophore as highly effective sensor for hypoxic tumor cells: design, imaging and evaluation

Journal of Fluorescence
Min DaiYin You

Abstract

Based on the characteristics of a nitro-group, which can be partially or totally reduced to an amino-group in hypoxic cells, two series of hypoxic sensors containing 7H-Benzimidazole [2,1-a]benz[de]isoquinolin-7-one cores with nitro groups in different positions were designed, synthesized and evaluated. The target compounds exhibited significantly different fluorescence characteristics (fluorescence enhancement or quenching). The strong fluorescences of some partially reduced compounds could be explained through the examination of their infrared spectra, which showed a restriction of the nitro-group vibration. These compounds exhibited significant hypoxic-oxic fluorescence differences not only in numerical values but also in their fluorescent imaging properties as reported for the first time.

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Citations

Mar 16, 2013·Chemical Research in Toxicology·Anuruddha RajapakseKent S Gates
Mar 1, 2016·Chemical Communications : Chem Comm·Robert B P Elmes
Dec 9, 2017·Organic & Biomolecular Chemistry·Xingye YangMinyong Li
Jul 1, 2010·Chemical Communications : Chem Comm·Xuhong QianWeipin Zhu
Apr 12, 2014·Chemical Society Reviews·Zhigang YangJong Seung Kim
Mar 14, 2013·The Biochemical Journal·Jiechuang SuWilliam R Wilson
Jun 19, 2012·Chemical Reviews·Yuming YangFuyou Li

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