Versatile routes toward functional, water-soluble nanoparticles via trifluoroethylester-PEG-thiol ligands

Langmuir : the ACS Journal of Surfaces and Colloids
Andrew H Latham, Mary Elizabeth Williams

Abstract

This paper reports the synthesis of a trifluoroethylester-PEG-thiol ligand (TFEE-PEG-SH) and its use to create water-soluble, chemically functional Au metal and FePt magnetic nanoparticles. The trifluoroethylester terminus facilitates attachment of any primary-amine-containing molecule via amide bond formation at room temperature without the use of coupling agents. Three possible routes of nanoparticle functionalization are demonstrated: synthesis of Au nanoparticles in the presence of functionalized R-PEG-SH; ligand-exchange of R-PEG-SH onto both Au and FePt nanoparticles; and exchange of TFEE-PEG-SH onto Au nanoparticles followed by subsequent amide condensation. A series of primary-amine-containing molecules, including biotin and fluorescamine, are easily attached to the water-soluble particles, and the resulting materials are characterized by NMR, UV-visible absorption, and emission spectroscopies.

References

Mar 29, 2000·Accounts of Chemical Research·A C TempletonR W Murray
Apr 25, 2002·Journal of the American Chemical Society·Sandra J RosenthalRandy D Blakely
Jun 13, 2002·Journal of the American Chemical Society·Yang Song, Royce W Murray
Dec 31, 2002·Journal of Colloid and Interface Science·S NeveuD Talbot
Apr 17, 2003·Journal of the American Chemical Society·Alexander G TkachenkoDaniel L Feldheim
Jan 8, 2004·Journal of the American Chemical Society·Shouheng SunGuanxiong Li
Mar 18, 2004·Journal of the American Chemical Society·Chenjie XuBing Xu
May 13, 2004·Journal of the American Chemical Society·Jwa-Min NamChad A Mirkin
Sep 9, 2004·Chemical Reviews·Brian L CushingCharles J O'Connor
Nov 30, 2004·Nature Materials·Jongnam ParkTaeghwan Hyeon
Feb 24, 2005·Journal of the American Chemical Society·Rui GuoRoyce W Murray
Mar 23, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·David B RobinsonShan X Wang
Apr 14, 2005·Nano Letters·Christopher LooRebekah Drezek
May 10, 2005·Angewandte Chemie·Petre IonitaVictor Chechik
Jun 10, 2005·Nano Letters·Omid VeisehMiqin Zhang
Jun 23, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Robert L DonkersRoyce W Murray
Aug 2, 2005·Analytical Chemistry·Andrew H LathamMary Elizabeth Williams

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Citations

Apr 13, 2013·Molecules and Cells·Jae-Hyun LeeJinwoo Cheon
Jul 30, 2011·The Analyst·Jason R StephensMary Elizabeth Williams
Jul 24, 2012·Therapeutic Delivery·Roland StoneFrank Alexis
Sep 18, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Nereida MejíasMar Tristany
Feb 27, 2013·The Journal of Organic Chemistry·Shoji MatsumotoMotohiro Akazome
Apr 5, 2014·Drug Metabolism Reviews·Anamaria OrzaAlexandru Biris
Sep 5, 2014·ACS Applied Materials & Interfaces·Jiuxing LiChaoyong James Yang
Jun 25, 2008·Angewandte Chemie·Young-wook JunJinwoo Cheon
Jul 27, 2010·Journal of Polymer Science. Part A, Polymer Chemistry·Kim Y van Berkel, Craig J Hawker
Aug 28, 2015·Angewandte Chemie·Norihiro Mizoshita, Shinji Inagaki
Oct 9, 2015·Nanoscale Research Letters·Cristian IacovitaConstantin M Lucaciu
Jul 30, 2014·Biosensors & Bioelectronics·Michael ThompsonAlexander Romaschin
Dec 3, 2013·Chemical Society Reviews·Loris Rizzello, Pier Paolo Pompa
Apr 30, 2013·The Journal of Physical Chemistry. C, Nanomaterials and Interfaces·Alexander B NepomnyashchiiJoel Rosenthal
Dec 3, 2016·The Analyst·Ashley M SmithJill E Millstone
Nov 15, 2020·Chemical Communications : Chem Comm·Zhiyuan WeiXiaohu Xia
Mar 20, 2010·Analytical Chemistry·Jason R StephensMary Elizabeth Williams
May 8, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Lisa MausRoberto Fiammengo
Jun 22, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Tuha VongHan Zuilhof
Jun 15, 2007·Chemical Reviews·Jennifer A DahlJames E Hutchison
Nov 7, 2009·Analytical Chemistry·Jacob S BeveridgeMary Elizabeth Williams
Apr 11, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Andrew H Latham, Mary Elizabeth Williams
Jun 15, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Lesley E RussellMichael C Leopold
Nov 17, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Layal L RouhanaJoseph B Schlenoff
Jun 12, 2008·Analytical Chemistry·Jenny AveyardRobert Wilson
Feb 7, 2008·Accounts of Chemical Research·Andrew H Latham, Mary Elizabeth Williams
Jul 8, 2011·Journal of the American Chemical Society·Shiyi ZhangKaren L Wooley
Dec 15, 2006·Analytical Chemistry·Sarah J HurstChad A Mirkin
Aug 21, 2007·Journal of the American Chemical Society·LiNa LooStefan Franzen
Jun 26, 2007·Analytical Chemistry·Andrew H LathamMary Elizabeth Williams

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