Versatility of cell-penetrating peptides for intracellular delivery of siRNA

Drug Delivery
Tejinder SinghJungkyun Im

Abstract

The plasma membrane is a large barrier to systemic drug delivery into cells, and it limits the efficacy of drug cargo. This issue has been overcome using cell-penetrating peptides (CPPs). CPPs are short peptides (6-30 amino acid residues) that are potentially capable of intracellular penetration to deliver drug molecules. CPPs broadened biomedical applications and provide a means to deliver a range of biologically active molecules, such as small molecules, proteins, imaging agents, and pharmaceutical nanocarriers, across the plasma membrane with high efficacy and low toxicity. This review is focused on the versatility of CPPs and advanced approaches for siRNA delivery.

References

Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A JoliotA Prochiantz
Nov 23, 2000·Proceedings of the National Academy of Sciences of the United States of America·P A WenderJ B Rothbard
Sep 26, 2001·Experimental Cell Research·A Elmquist Langel U
Jan 17, 2002·Current Opinion in Cell Biology·Dorothy A Schafer
Sep 3, 2002·Chemistry & Biology·Angela D RaginJean Chmielewski
Nov 5, 2002·Bioorganic & Medicinal Chemistry·Changshou GaoKim D Janda
Nov 27, 2002·Biochemistry·Kristen SadlerJames P Tam
Dec 30, 2004·The Journal of Cell Biology·Nathalie SauvonnetAlice Dautry-Varsat
Feb 3, 2005·Nature Reviews. Molecular Cell Biology·Christine Le Roy, Jeffrey L Wrana
Sep 3, 2005·Analytical Biochemistry·Külliki SaarUlo Langel
Nov 8, 2005·The Journal of Biological Chemistry·Melanie Rhee, Pamela Davis
Mar 21, 2006·Biochimica Et Biophysica Acta·Edwige GrosGilles Divita
Mar 21, 2006·Biochimica Et Biophysica Acta·Sílvia PujalsErnest Giralt
Aug 31, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gisela TünnemannM Cristina Cardoso
Apr 28, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Pontus LundbergU Langel
Nov 7, 2007·Journal of the American Chemical Society·Douglas S Daniels, Alanna Schepartz
Nov 27, 2007·Advanced Drug Delivery Reviews·Sébastien DeshayesGilles Divita
Dec 22, 2007·Expert Opinion on Drug Delivery·Camilla Foged, Hanne Moerck Nielsen
Jan 12, 2008·Advanced Drug Delivery Reviews·Sílvia Pujals, Ernest Giralt
Mar 18, 2008·Biology of the Cell·May C MorrisGilles Divita
Jun 20, 2008·Organic & Biomolecular Chemistry·Kelly M StewartShana O Kelley
Jul 22, 2008·Nanomedicine : Nanotechnology, Biology, and Medicine·Daniela Reischl, Andreas Zimmer
Dec 5, 2008·Bioconjugate Chemistry·Judith MuellerPrisca Boisguerin
Mar 25, 2009·British Journal of Pharmacology·Frederic HeitzGilles Divita
May 26, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ayman El-SayedHideyoshi Harashima
Jul 16, 2009·Protein and Peptide Letters·P JoanneC El Amri
Mar 20, 2010·Molecular BioSystems·Rupa Sawant, Vladimir Torchilin
Jun 15, 2010·The AAPS Journal·Jie WangJessie L-S Au
Mar 23, 2011·Immunology and Cell Biology·Jet Phey Lim, Paul A Gleeson
Apr 15, 2011·Current Opinion in Biotechnology·Arjen van den Berg, Steven F Dowdy
May 7, 2011·Journal of the American Chemical Society·Jessica R MarksWilliam C Wimley
Jun 21, 2011·Journal of Biophysics·Fatemeh MadaniAstrid Gräslund
Sep 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Tracy Hsu, Samir Mitragotri
Jan 3, 2012·Accounts of Chemical Research·Ikuhiko NakaseShiroh Futaki
Jan 21, 2012·Nature Reviews. Drug Discovery·Ryszard KoleSidney Altman
Feb 16, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Hisaaki HiroseShiroh Futaki
Apr 3, 2012·Drug Discovery Today·Francesca Milletti

❮ Previous
Next ❯

Citations

Feb 1, 2019·Advanced Materials·Bahareh Khezri, Martin Pumera
Jul 30, 2020·Future Medicinal Chemistry·Annarita FalangaStefania Galdiero
Dec 18, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Olujide O OlubiyiBirgit Strodel
Nov 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mariya I MeschaninovaAlya G Venyaminova
Dec 2, 2020·Nanomaterials·Matthieu SimonNadir Bettache
Aug 14, 2019·Translational Research : the Journal of Laboratory and Clinical Medicine·James C CummingsAndrew Jakymiw
Nov 18, 2020·Biomedicines·Kyungwoo LeeJonghoon Choi
Nov 13, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ling DingDavid Oupický
Jan 27, 2021·Molecular Pharmaceutics·Ryley HallHamidreza Montazeri Aliabadi
Jun 17, 2021·Journal of Peptide Science : an Official Publication of the European Peptide Society·Christos PapadopoulosVassilios Tsikaris
Aug 18, 2021·Acta Pharmaceutica Sinica. B·Makhloufi ZoulikhaWei He
Aug 28, 2021·International Journal of Molecular Sciences·Shabnam TarvirdipourCornelia G Palivan

❮ Previous
Next ❯

Methods Mentioned

BETA
amidation
transfect
GTPase
transfection
gene knockdown

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.