Versatility of global transcriptional regulators in alpha-Proteobacteria: from essential cell cycle control to ancillary functions

FEMS Microbiology Reviews
Gaël PanisPatrick H Viollier

Abstract

Recent data indicate that cell cycle transcription in many alpha-Proteobacteria is executed by at least three conserved functional modules in which pairs of antagonistic regulators act jointly, rather than in isolation, to control transcription in S-, G2- or G1-phase. Inactivation of module components often results in pleiotropic defects, ranging from cell death and impaired cell division to fairly benign deficiencies in motility. Expression of module components can follow systemic (cell cycle) or external (nutritional/cell density) cues and may be implemented by auto-regulation, ancillary regulators or other (unknown) mechanisms. Here, we highlight the recent progress in understanding the molecular events and the genetic relationships of the module components in environmental, pathogenic and/or symbiotic alpha-proteobacterial genera. Additionally, we take advantage of the recent genome-wide transcriptional analyses performed in the model alpha-Proteobacterium Caulobacter crescentus to illustrate the complexity of the interactions of the global regulators at selected cell cycle-regulated promoters and we detail the consequences of (mis-)expression when the regulators are absent. This review thus provides the first detailed mech...Continue Reading

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Citations

Feb 13, 2016·Current Opinion in Microbiology·Justine Collier
Oct 20, 2015·Current Opinion in Microbiology·Silvia Ardissone, Patrick H Viollier
Mar 10, 2016·The ISME Journal·Marie de BarsyPatrick H Viollier
May 31, 2016·Journal of Inorganic Biochemistry·Gianluca D'AbroscaGaetano Malgieri
Oct 19, 2016·Current Opinion in Microbiology·Keren LaskerLucy Shapiro
Nov 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Balaganesh JanakiramanSunish Kumar Radhakrishnan
Feb 2, 2018·Bioinorganic Chemistry and Applications·Valeria SivoGaetano Malgieri
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Oct 11, 2019·Nucleic Acids Research·Marie DelabyPatrick H Viollier
Sep 25, 2020·Biological Chemistry·Muriel C F van Teeseling, Martin Thanbichler
Aug 1, 2016·FEMS Microbiology Reviews·Satish Adhikari, Patrick D Curtis
Apr 20, 2019·Scientific Reports·Yolanda Elisabet González-FloresEduardo Santero
Jun 11, 2020·Scientific Reports·Gianluca D'AbroscaGaetano Malgieri
Nov 22, 2017·Current Opinion in Microbiology·Johann MignoletPatrick H Viollier
Feb 20, 2021·Proceedings of the National Academy of Sciences of the United States of America·Marie DelabyPatrick H Viollier
Dec 5, 2017·Trends in Microbiology·Matthieu Bergé, Patrick H Viollier
May 18, 2021·Frontiers in Microbiology·Jürgen TomaschAndrew S Lang
Jun 19, 2021·Frontiers in Microbiology·Inoka P MenikpuragePaola E Mera

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