Versatility of the mitochondrial protein import machinery

Nature Reviews. Molecular Cell Biology
N Pfanner, A Geissler

Abstract

The vast majority of mitochondrial proteins are synthesized in the cytosol and are imported into mitochondria by protein machineries located in the mitochondrial membranes. It has become clear that hydrophilic as well as hydrophobic preproteins use a common translocase in the outer mitochondrial membrane, but diverge to two distinct translocases in the inner membrane. The translocases are dynamic, high-molecular-weight complexes that have to provide specific means for the recognition of preproteins, channel formation and generation of import-driving forces.

References

Dec 1, 1991·The Journal of Cell Biology·U WienhuesW Neupert
Dec 1, 1990·The Journal of Cell Biology·H F StegerN Pfanner
Apr 1, 1989·European Journal of Biochemistry·G von HeijneR G Herrmann
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·G Blobel
Feb 24, 1995·The Journal of Biological Chemistry·F GärtnerN Pfanner
Jan 10, 1998·The EMBO Journal·A MatouschekG Schatz
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·K HellR A Stuart
Sep 25, 1998·The Journal of Biological Chemistry·C KnoxO Pines

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Citations

Jun 15, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Shuo Cheng ZhangPaul R Murphy
Sep 14, 2010·Analytical and Bioanalytical Chemistry·Markus LangsdorfBernhard Spengler
Aug 27, 2005·Mitochondrion·José R BlesaJosé Hernández-Yago
Apr 9, 2005·Trends in Biochemical Sciences·Johannes M Herrmann, Kai Hell
Apr 30, 2003·Biophysical Journal·Concepción MuroMaría Luisa Campo
Feb 13, 2003·Journal of Molecular Biology·Peter RehlingChristof Meisinger
Mar 12, 2003·Journal of Molecular Biology·Nils WiedemannKaye N Truscott
Oct 18, 2002·Current Opinion in Cell Biology·Nikolaus Pfanner, Nils Wiedemann
Feb 13, 2003·Current Opinion in Structural Biology·Andreas Matouschek
Sep 1, 2001·Trends in Cell Biology·W H KunauW Girzalsky
Aug 21, 2002·Trends in Cell Biology·Agnieszka ChacinskaChris Meisinger
Jan 5, 2002·Trends in Microbiology·Beate Sodeik, Jacomine Krijnse-Locker
Feb 25, 2003·Trends in Microbiology·Johannes M Herrmann
Jun 26, 2002·Fungal Genetics and Biology : FG & B·Holger ProkischBenedikt Westermann
Jan 24, 2002·Trends in Plant Science·Xiao-Ping Zhang, Elzbieta Glaser
Aug 23, 2002·Nature·Andrew J Roger, Jeffrey D Silberman
Feb 21, 2003·Nature·R John Ellis
Apr 26, 2008·Cell Death and Differentiation·A J ValentijnA P Gilmore
Aug 23, 2002·Nature·Bryony A P WilliamsT Martin Embley
Jan 18, 2005·Nature Immunology·Fabian KöhlerHassan Jumaa
Jul 3, 2004·Nature Reviews. Molecular Cell Biology·Peter RehlingNikolaus Pfanner
Jun 13, 2006·Nature Structural & Molecular Biology·Yunkun Wu, Bingdong Sha
Nov 8, 2002·Molecular Microbiology·Mario F FeldmanGuy R Cornelis
Jun 6, 2002·The Plant Journal : for Cell and Molecular Biology·Ryan ListerA Harvey Millar
Jun 13, 2008·Journal de la Société de biologie·Chantal Wrutniak-CabelloGérard Cabello
Mar 12, 2008·Proceedings of the National Academy of Sciences of the United States of America·Winnie S LiangDietrich A Stephan
Aug 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Chun ZhouSerge Przedborski
Nov 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Patrick D D'SilvaElizabeth A Craig
Sep 22, 2009·The Journal of Biological Chemistry·Hayashi YamamotoToshiya Endo
Apr 16, 2010·The Journal of Biological Chemistry·Arvind Vittal GoswamiPatrick D'Silva
Aug 6, 2004·The Proceedings of the Nutrition Society·David A Hood, Anna-Maria Joseph
Jan 5, 2006·The Journal of Experimental Medicine·Ronit Vogt SionovEitan Yefenof
May 15, 2002·Molecular Biology of the Cell·Chika HorieKatsuyoshi Mihara
Nov 5, 2004·Molecular Biology of the Cell·Takashi TatsutaThomas Langer
Jul 11, 2006·Molecular Biology of the Cell·Chiang-Hung ChouHsin-Fang Yang-Yen

❮ Previous
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