Vertebral coccidioidomycosis: presentation and multidisciplinary management

The American Journal of Medicine
Larissa A SzeykoRodney D Adam

Abstract

Vertebral involvement is a severe complication of infection caused by Coccidioides species. We conducted a retrospective review of patients diagnosed with vertebral coccidioidomycosis at an academic medical center between 1996 and 2009. We identified 39 cases of vertebral coccidioidomycosis. Thirty-four patients (79%) were male, and 23 patients (61%) were black. Black patients were overrepresented in comparison with all other patients by a 50-fold odds ratio (95% confidence interval, 26-95). Only 8 patients (20%) were immunocompromised, including 7 who had received systemic steroids. The number of infected vertebrae ranged from 1 to 24; 8 patients (21%) had epidural involvement. All patients received a triazole as part of medical therapy, and 20 patients also received amphotericin B, typically early in the course. Twenty-six patients (67%) required surgery, 18 of whom also required hardware placement. The most common indication for surgery was pain, but 7 patients had neurologic compromise. No patients developed recurrent or refractory infection at the site of surgical debridement, but 6 patients experienced disease relapse after stopping antifungal therapy. Vertebral infection caused by Coccidioides species requires a multispe...Continue Reading

References

Sep 26, 1977·JAMA : the Journal of the American Medical Association·L J WesseliusE P Gall
Apr 20, 1995·The New England Journal of Medicine·D A Stevens
Jul 1, 1993·Annals of Internal Medicine·J N GalgianiJ R Graybill
May 1, 1996·Skeletal Radiology·M A ZeppaL S Steinbach
Sep 2, 1998·AJR. American Journal of Roentgenology·E M OlsonD Smilovitz
Jul 12, 2002·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Hitomi NakamuraAikichi Iwamoto
May 20, 2004·AJR. American Journal of Roentgenology·Na-Young JungJae-Young Byun
May 24, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gregory M AnsteadJohn R Graybill
May 19, 2006·Emerging Infectious Diseases·Lisa ValdiviaJohn N Galgiani
Jul 11, 2007·Clinical Orthopaedics and Related Research·Anil K Jain
Aug 9, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Antonino CatanzaroJohn N Galgiani
Mar 8, 2008·AJR. American Journal of Roentgenology·Gregory E WildeJames F Lally
Jan 14, 2009·Antimicrobial Agents and Chemotherapy·Alison FreifeldL Joseph Wheat
Jul 29, 2009·The American Journal of Medicine·Rodney D AdamMihra S Taljanovic

❮ Previous
Next ❯

Citations

Feb 20, 2014·BMC Medical Imaging·Yi-Chen LiRobert Lor Randall
Dec 11, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Lee A TanVincent C Traynelis
Jan 8, 2016·Infectious Disease Clinics of North America·Nathan W Stockamp, George R Thompson
Jan 9, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joshua Fierer
Jul 15, 2015·Surgical Neurology International·Nikolay L MartirosyanAli A Baaj
Jul 30, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John N GalgianiNicholas Theodore
Aug 26, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John N GalgianiNicholas Theodore
Oct 16, 2015·Revista Do Instituto De Medicina Tropical De São Paulo·Neil M Ampel
Feb 7, 2017·Clinical Nuclear Medicine·John Randolph DrydenEugene David Silverman
Apr 27, 2018·JAAPA : Official Journal of the American Academy of Physician Assistants·Brandon M Carius, Charles J Kambe
Mar 19, 2020·Journal of General Internal Medicine·McKinsey M PillsburyJennifer M Babik
Nov 8, 2018·Osong Public Health and Research Perspectives·Seung-Hak ChoYoung-Kwon Kim
Jul 10, 2019·Brain Sciences·Dinesh RamanathanEsther Kim
Jun 14, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Alfredo G PuingAruna K Subramanian
May 22, 2021·Infectious Disease Clinics of North America·Derek J Bays, George R Thompson
Apr 3, 2021·Ophthalmic Plastic and Reconstructive Surgery·Donovan S ReedMarie Somogyi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.