Vertebral morphometry derived from digital images

AJR. American Journal of Roentgenology
M S RosolD I Rosenthal

Abstract

We describe a method for capturing measurement data directly from digitized images using specialized software and high-resolution workstations. We have evaluated the reliability, accuracy, and reproducibility of this method in an international clinical trial involving vertebral morphometry. Accuracy was determined using clinical radiographs measured with vernier calipers and a film phantom. Intra- and interobserver variabilities were assessed, and longitudinal reproducibility was evaluated. As part of the trial, spinal radiographs were collected from more than 200 international health care facilities and digitized at four screening centers. Digitized images were stored and sent to our central facility for morphometry and archiving. Timeliness and variability of the process were tracked. Relative accuracy was nearly 100%. Correlation with clinical measurements was high (r = .96; p < .05). The mean coefficient of variation for interobserver variability was 2%. Intraobserver variation was 3-5%. The coefficient of variation for longitudinal reproducibility ranged from 4% to 6%. After 9 months of operation, our trial included 9494 patients. Of approximately 36,000 radiographs, 98% passed quality review. Only 1% of vertebral levels w...Continue Reading

Citations

Oct 17, 2008·Radiologic Clinics of North America·Giuseppe GuglielmiWilfred C G Peh
Jan 6, 2001·Journal of Manipulative and Physiological Therapeutics·D E HarrisonS Harmon
Jan 16, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Brian LentleUNKNOWN Vertebral Fracture Research Groups of the CaMos, STOPP, and Rotterdam Studies
Jun 2, 1997·The Medical Journal of Australia·M Silberstein, J Hornstein

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