Vertebrate CASTOR is required for differentiation of cardiac precursor cells at the ventral midline.

Developmental Cell
Kathleen S Christine, Frank L Conlon

Abstract

The CASTOR (CST) transcription factor was initially identified for its role in maintaining stem cell competence in the Drosophila dorsal midline. Here we report that Xenopus CST affects cardiogenesis. In CST-depleted embryos, cardiomyocytes at the ventral midline arrest and are maintained as cardiac progenitors, while cells in more dorsal regions of the heart undergo their normal program of differentiation. Cardia bifida results from failed midline differentiation, even though cardiac cell migration and initial cell fate specification occur normally. Our fate mapping studies reveal that this ventral midline population of cardiomyocytes ultimately gives rise to the outer curvature of the heart; however, CST-depleted midline cells overproliferate and remain a coherent population of nonintegrated cells positioned on the outer wall of the ventricle. These midline-specific requirements for CST suggest the regulation of cardiomyocyte differentiation is regionalized along a dorsal-ventral axis and that this patterning occurs prior to heart tube formation.

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Citations

Apr 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yu-Chiuan ChangDenise J Montell
Dec 15, 2010·Circulation Research·Sylvia M EvansMargaret L Kirby
May 4, 2011·Birth Defects Research. Part A, Clinical and Molecular Teratology·Erin KaltenbrunFrank L Conlon
Jan 21, 2012·International Journal of Cancer. Journal International Du Cancer·Martina SchmitzMatthias Dürst
Dec 11, 2013·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Marta S Charpentier, Frank L Conlon
Mar 19, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Nirav M AminFrank L Conlon
Aug 4, 2018·Proceedings of the National Academy of Sciences of the United States of America·Pierre MattarMichel Cayouette
Mar 7, 2018·Journal of Experimental & Clinical Cancer Research : CR·Ji-Long WangLian-Yue Yang
Jan 19, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Xing-Biao QiuYi-Qing Yang
Mar 15, 2018·Pediatric Cardiology·Wen Lin, Deqiang Li
Jan 1, 2015·Neurogenesis·Pierre Mattar, Michel Cayouette
Jun 4, 2016·Journal of Cardiovascular Development and Disease·Annemarie Hempel, Michael Kühl
Jul 17, 2020·ELife·Peter HegerThomas Wiehe
May 3, 2013·Development·Panna TandonFrank L Conlon
Jun 20, 2021·Seminars in Cell & Developmental Biology·Megan RowtonIvan P Moskowitz

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