Apr 16, 1998

Vertebrate genome evolution and the zebrafish gene map

Nature Genetics
J H PostlethwaitW S Talbot

Abstract

In chordate phylogeny, changes in the nervous system, jaws, and appendages transformed meek filter feeders into fearsome predators. Gene duplication is thought to promote such innovation. Vertebrate ancestors probably had single copies of genes now found in multiple copies in vertebrates and gene maps suggest that this occurred by polyploidization. It has been suggested that one genome duplication event occurred before, and one after the divergence of ray-finned and lobe-finned fishes. Holland et al., however, have argued that because various vertebrates have several HOX clusters, two rounds of duplication occurred before the origin of jawed fishes. Such gene-number data, however, do not distinguish between tandem duplications and polyploidization events, nor whether independent duplications occurred in different lineages. To investigate these matters, we mapped 144 zebrafish genes and compared the resulting map with mammalian maps. Comparison revealed large conserved chromosome segments. Because duplicated chromosome segments in zebrafish often correspond with specific chromosome segments in mammals, it is likely that two polyploidization events occurred prior to the divergence of fish and mammal lineages. This zebrafish gene ...Continue Reading

  • References16
  • Citations407

Citations

Mentioned in this Paper

Vertebrates
Jaw
lobe-finned fishes <coelacanthiform>
Genome
Genes, Reiterated
Entire Nervous System
Fish <Chondrichthyes>
Genome Mapping
Tandem
Nervous System Structure

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