Verteporfin-Loaded Polymeric Microparticles for Intratumoral Treatment of Brain Cancer

Molecular Pharmaceutics
Sagar R ShahAlfredo Quinones-Hinojosa

Abstract

Glioblastoma (GBMs) is the most common and aggressive type of primary brain tumor in adults with dismal prognosis despite radical surgical resection coupled with chemo- and radiotherapy. Recent studies have proposed the use of small-molecule inhibitors, including verteporfin (VP), to target oncogenic networks in cancers. Here we report efficient encapsulation of water-insoluble VP in poly(lactic- co-glycolic acid) microparticles (PLGA MP) of ∼1.5 μm in diameter that allows tunable, sustained release. Treatment with naked VP and released VP from PLGA MP decreased cell viability of patient-derived primary GBM cells in vitro by ∼70%. Moreover, naked VP treatment significantly increased radiosensitivity of GBM cells, thereby enhancing overall tumor cell killing ability by nearly 85%. Our in vivo study demonstrated that two intratumoral administrations of sustained slow-releasing VP-loaded PLGA MPs separated by two weeks significantly attenuated tumor growth by ∼67% in tumor volume in a subcutaneous patient-derived GBM xenograft model over 26 d. Additionally, our in vitro data indicate broader utility of VP for treatment for other solid cancers, including chordoma, malignant meningioma, and various noncentral nervous system-derived ...Continue Reading

References

Jan 16, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Janny X ZhangRon Boch
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Aug 9, 2006·Proceedings of the National Academy of Sciences of the United States of America·Michael OverholtzerDaniel A Haber
Jun 28, 2011·Journal of Neurosurgery·Wesley HsuAlfredo Quiñones-Hinojosa
Feb 4, 2012·The Lancet Oncology·Brian P WalcottManuel J Ferreira
Mar 16, 2012·Neurosurgery·Wesley HsuAlfredo Quinones-Hinojosa
May 12, 2012·Polymers·Hirenkumar K Makadia, Steven J Siegel
Oct 17, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F-W KrethUNKNOWN German Glioma Network
May 9, 2014·Oncotarget·Erica LorenzettoPiergiorgio Modena
Jun 3, 2014·Cancer Cell·Fa-Xing YuKun-Liang Guan
Jul 11, 2014·Journal of Hepatology·Andrea PerraAmedeo Columbano
Oct 29, 2014·Journal of Neuro-oncology·Dimitrios MathiosMichael Lim
Mar 21, 2015·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·O van TellingenH E de Vries
Jun 15, 2016·Cancer Cell·Francesca ZanconatoStefano Piccolo
Sep 8, 2016·Journal of Experimental & Clinical Cancer Research : CR·Hui LiWenli Feng
Sep 24, 2016·International Journal of Nanomedicine·Diogo Silva PellosiFabiana Quaglia
Dec 30, 2016·Nature Reviews. Clinical Oncology·Guido ReifenbergerMichael Weller
Mar 7, 2017·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Hong WangWenping Wang
Apr 19, 2017·Drug Delivery and Translational Research·Alex E GrillJayanth Panyam
Aug 10, 2017·Scientific Reports·Ahmad Al-MoujahedDemetrios G Vavvas
Oct 12, 2017·Cell Reports·Sagar R ShahAlfredo Quiñones-Hinojosa
Dec 21, 2017·Brain Sciences·Montserrat Lara-VelazquezAlfredo Quinones-Hinojosa
Jan 6, 2018·Nature Reviews. Neurology·Matthias PreusserChristian Mawrin

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Citations

Sep 29, 2020·Frontiers in Oncology·Asunción Espinosa-SánchezAmancio Carnero
Oct 2, 2020·Journal of Photochemistry and Photobiology. B, Biology·Daphne Christine Salles de OliveiraAndré Luiz Tessaro
Feb 3, 2021·Pharmaceuticals·Abigail KoehlerSoma Sengupta
Nov 12, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Krishanthan VigneswaranRenee D Read
Aug 6, 2021·Advanced Healthcare Materials·Jayoung KimSamir Mitragotri
May 24, 2019·Molecular Pharmaceutics·Monika MajerskáFrantišek Štěpánek
Jun 4, 2020·ACS Central Science·Marta OverchukGang Zheng

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