Verteporfin photodynamic therapy induced apoptosis in choroidal neovascular membranes.

The British Journal of Ophthalmology
K PetermeierSalvatore Grisanti

Abstract

To evaluate the impact of verteporfin photodynamic therapy (PDT) on the induction of apoptosis in choroidal neovascular membranes (CNV) secondary to age related macular degeneration. Retrospective review of 22 surgically excised CNV. 12 of these patients had been treated with PDT 3-146 days previously. Apoptotic cells were detected with the TUNEL technique and compared to the expression of CD34 (endothelial cells, EC), CD105 (activated endothelial cells), Ki-67 (proliferation marker), and cytokeratin18 (retinal pigment epithelial cells, RPE). CNV excised 3 days after PDT were characterised both by collapsed and patent vessels. The EC displayed a statistical significant positive TUNEL reaction when compared to the remaining treated CNV (p < 0.001) and untreated CNV (P = 0.002). The proliferative activity was reduced. CNV excised 1-5 months after PDT displayed a patent vascularisation and high proliferative activity. All membranes either treated or untreated disclosed only sporadic TUNEL positive cells within the stroma and the RPE. Verteporfin PDT leads to selective and effective damage of EC within CNV. Both patent and occluded vessels were lined by apoptotic EC. This finding and the increased expression of proliferation marker...Continue Reading

References

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Citations

Mar 21, 2007·Angiogenesis·John BradleyGregory S Robinson
Aug 27, 2009·Photochemistry and Photobiology·Elodie DebefveHubert van den Bergh
Sep 22, 2006·The British Journal of Ophthalmology·Olcay TatarSalvatore Grisanti
May 4, 2007·The British Journal of Ophthalmology·Olcay TatarSalvatore Grisanti
Aug 12, 2009·Clinical Ophthalmology·Jean Pierre HubschmanSteven D Schwartz
Sep 16, 2010·Angiogenesis·Patrycja Nowak-SliwinskaArjan W Griffioen
Jul 6, 2012·Expert Opinion on Drug Metabolism & Toxicology·Focke Ziemssen, Heinrich Heimann
Nov 28, 2006·Dermatologic Clinics·Amy Forman Taub
Jun 26, 2009·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Muhammad Amer AwanYit C Yang
Nov 1, 2007·Veterinary Ophthalmology·Elizabeth A GiulianoSheryl A Tucker
Jul 16, 2008·Progress in Retinal and Eye Research·Salvatore Grisanti, Olcay Tatar

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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