Verteporfin therapy of subfoveal choroidal neovascularization in age-related macular degeneration: two-year results of a randomized clinical trial including lesions with occult with no classic choroidal neovascularization--verteporfin in photodynamic therapy report 2

American Journal of Ophthalmology
Verteporfin In Photodynamic Therapy Study Group

Abstract

To determine if photodynamic therapy with verteporfin (Visudyne; Novartis AG, Bülach, Switzerland), termed verteporfin therapy, can safely reduce the risk of vision loss compared with a placebo (with sham treatment) in patients with subfoveal choroidal neovascularization caused by age-related macular degeneration who were identified with a lesion composed of occult with no classic choroidal neovascularization, or with presumed early onset classic choroidal neovascularization with good visual acuity letter score. This was a double-masked, placebo-controlled (sham treatment), randomized, multicenter clinical trial involving 28 ophthalmology practices in Europe and North America. The study population was patients with age-related macular degeneration, with subfoveal choroidal neovascularization lesions measuring no greater than 5400 microm in greatest linear dimension with either 1) occult with no classic choroidal neovascularization, best-corrected visual acuity score of at least 50 (Snellen equivalent approximately 20/100), and evidence of hemorrhage or recent disease progression; or 2) evidence of classic choroidal neovascularization with a best-corrected visual acuity score of at least 70 (better than a Snellen equivalent of a...Continue Reading

Citations

Jul 24, 2012·Advanced Drug Delivery Reviews·Sacha NoimarkIvan P Parkin
Mar 9, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·M E J van VelthovenF D Verbraak
Jan 15, 2014·The British Journal of Ophthalmology·F BucherF Bock
Aug 20, 2014·The British Journal of Ophthalmology·Ursula Schmidt-ErfurthUNKNOWN European Society of Retina Specialists
Mar 12, 2004·American Journal of Ophthalmology·Diana V DoSusan B Bressler
Aug 12, 2014·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Yiannis IordanousThomas G Sheidow
Jan 18, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Rufino M SilvaJ G Cunha-Vaz
Jun 15, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Kristel MaaijweeJan van Meurs
Jul 28, 2007·Acta Ophthalmologica Scandinavica·Ursula M Schmidt-ErfurthUNKNOWN European Society for Retina Specialists' Guidelines Committee (EURETINA)
Mar 12, 2004·American Journal of Ophthalmology·Paul Sternberg, Hilel Lewis
Mar 12, 2004·American Journal of Ophthalmology·Hans E Grossniklaus, W Richard Green
Mar 12, 2004·American Journal of Ophthalmology·Frank G HolzAlan C Bird
Nov 21, 2001·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·S SharmaS M Sharma
Apr 13, 2012·Journal of Ophthalmology·Young Gun ParkYoung Jung Roh
Mar 21, 2002·Journal of Clinical Laser Medicine & Surgery·Thomas J Dougherty
Mar 27, 2002·The British Journal of Ophthalmology·P SullivanJ Sears
Jan 25, 2003·The British Journal of Ophthalmology·J B JonasJ Muliyil
Feb 25, 2003·The British Journal of Ophthalmology·S AbugreenU Chakravarthy
Dec 25, 2003·The British Journal of Ophthalmology·D M MarcusC N Samy
Jan 23, 2004·The British Journal of Ophthalmology·F GeliskenK U Bartz-Schmidt
Aug 20, 2004·The British Journal of Ophthalmology·G B Arden, J E Wolf
Apr 5, 2005·Retina·Sharon D SolomonUNKNOWN Submacular Surgery Trials Research Group
Apr 15, 2006·The British Journal of Ophthalmology·K PetermeierS Grisanti
Aug 25, 2006·The British Journal of Ophthalmology·U ChakravarthyS Wolf
Sep 22, 2006·The British Journal of Ophthalmology·Olcay TatarSalvatore Grisanti

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