Verteporfin therapy of subfoveal choroidal neovascularization in age-related macular degeneration: 5-year results of two randomized clinical trials with an open-label extension: TAP report no. 8

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
P K Kaiser, Treatment of Age-Related Macular Degeneration with Photodynamic Therapy (TAP) Study Group

Abstract

To report vision and safety outcomes up to 5 years from an extension of the Treatment of Age-related Macular Degeneration with Photodynamic Therapy (TAP) Investigation evaluating verteporfin therapy in patients with subfoveal choroidal neovascularization (CNV) in age-related macular degeneration. Patients who completed the 2-year randomized, placebo-controlled portion of the TAP Investigation could participate in the open-label extension study for an additional 3 years. Patients in the study extension received open-label verteporfin therapy in the study eye, fellow eye or both eyes, irrespective of original treatment assignment to placebo or verteporfin, if leakage from CNV was evident on fluorescein angiography. Follow-up visits occurred at 3-month intervals through to month 48, with a final follow-up visit at month 60. Of the 402 verteporfin-treated patients in the randomized trials, 320 (80%) enrolled in the extension study; 193 (60%) of these completed the extension study up to 5 years. Patients received an average of approximately two treatments during the 3 years of the extension study. Seventy-seven (62%) of the 124 verteporfin-treated patients with predominantly classic lesions at baseline who enrolled in the extension ...Continue Reading

References

Oct 17, 2002·Archives of Ophthalmology·Mark S BlumenkranzUNKNOWN Treatment of Age-Related Macular Degeneration with Photodynamic Therapy (TAP) Study Group
Apr 3, 2004·American Journal of Ophthalmology·Jennifer J ArnoldUNKNOWN Verteporfin in Photodynamic Therapy Study Group

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Citations

Dec 21, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·An TruongLevon M Khachigian
Aug 19, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Markus S LadewigNicole Eter
Jul 22, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·S Y CohenA Beresniak
Mar 6, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Leigh Spielberg, Anita Leys
Aug 12, 2010·Japanese Journal of Ophthalmology·Jinhyun KimHa Kyoung Kim
Jun 14, 2008·The New England Journal of Medicine·Rama D JagerJoan W Miller
May 22, 2007·Acta Ophthalmologica Scandinavica·Robert PedersenMichael Larsen
Aug 27, 2009·Photochemistry and Photobiology·Elodie DebefveHubert van den Bergh
May 19, 2007·The British Journal of Ophthalmology·Howard F Fine
Jan 24, 2013·Therapeutic Advances in Chronic Disease·Matthew Ohr, Peter K Kaiser
Aug 12, 2009·Clinical Ophthalmology·Albert J AugustinJanna Kirchhof
Apr 10, 2014·Case Reports in Ophthalmological Medicine·Panagiotis G MitropoulosEfstratios A Parikakis
Jun 1, 2013·Expert Review of Ophthalmology·Mohamed Al-ShabraweyAmany Tawfik
Oct 27, 2006·Expert Opinion on Emerging Drugs·Albert J Augustin, Indre Offermann
Aug 22, 2009·Expert Opinion on Investigational Drugs·James A DixonNaresh Mandava
Oct 19, 2010·Cutaneous and Ocular Toxicology·James Fen Taye Li Yim, Kevin P Crofts
Jun 3, 2009·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Jorge MataixAmparo Navea
Apr 9, 2010·Current Eye Research·Jun Woong MoonHyeong Gon Yu
Feb 4, 2012·Expert Opinion on Pharmacotherapy·Matthew Ohr, Peter K Kaiser
Jul 20, 2007·The Cochrane Database of Systematic Reviews·R WormaldK Henshaw
Sep 19, 2015·Journal of the Chinese Medical Association : JCMA·Tai-Chi LinChih-Chien Hsu
Jan 25, 2007·Acta Ophthalmologica Scandinavica·Gianni VirgiliUgo Menchini
Jan 24, 2007·International Ophthalmology Clinics·Sophia PachydakiJoan W Miller
Mar 16, 2012·The Cochrane Database of Systematic Reviews·Alex PollockUma Shahani
Apr 13, 2013·Pharmacotherapy·Lily K Cheung, Angie Eaton
Apr 11, 2018·Acta Ophthalmologica·Niko Kivinen
Nov 13, 2019·Biomedical Physics & Engineering Express·Zahra TavakoliMojgan Sheikhpour
Jun 15, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jiaxin ShenXiaofeng Fang

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