Vertical hepatitis C virus transmission is not related to mother-child class-1 HLA concordance

International Journal of Immunopathology and Pharmacology
C AzzariM Resti

Abstract

Mother-child human leukocyte antigen (HLA)diversity is protective for vertical transmission of some viruses. The aim of this study is to evaluate the role of mother-child HLA diversity on hepatitis C virus (HCV) vertical transmission. Forty consecutive HCV infected and 46 consecutive control uninfected children born to HCV-RNA positive mothers were evaluated for HLA class-1 type concordance with their mothers. No significant difference in the degree of HLA concordance was found between HCV infected and uninfected children both when A, B, C (p=0.30) and when only A and B alleles were evaluated (p=0.59). Mother-infant HLA concordance does not affect HCV vertical transmission.

References

Jul 6, 1991·Lancet·M M ThalerJ H Han
Mar 14, 1998·The Journal of Infectious Diseases·K S MacDonaldF A Plummer
Sep 5, 1998·The Journal of Infectious Diseases·M de MartinoA Vierucci
Jun 22, 2000·Journal of Medical Virology·M de MartinoA Vierucci
Sep 16, 2004·European Journal of Immunology·Francesca MasciopintoSergio Abrignani
Apr 20, 2005·Lipids in Health and Disease·Daniel Favre, Beat Muellhaupt
Dec 20, 2005·The Journal of Infectious Diseases·Robert J BiggarElizabeth M Maloney
Apr 26, 2007·Journal of Medical Virology·Giuseppe IndolfiMaurizio de Martino

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Citations

Mar 26, 2009·Journal of Medical Virology·Giuseppe Indolfi, Massimo Resti
Jan 29, 2016·World Journal of Gastroenterology : WJG·Pier-Angelo TovoSilvia Garazzino
Sep 19, 2014·World Journal of Hepatology·Grazia TosoneRaffaele Orlando

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