Vertical HIV-1 transmission: prophylaxis and paediatric follow-up

Placenta
M CarneiroM Valleé

Abstract

To study the effectiveness of anti-HIV therapy for vertical HIV-1 transmission based on the PACTG protocol 076, modified and adapted to Venezuela. Between March 1997 and March 2000, 74 HIV-1-infected women (15-42 years old) with 77 singleton pregnancies were evaluated. Zidovudine (ZDV) 500 mg/day (average 8 weeks) was begun after Western blot confirmatory tests, independent of CD4+ count or viral load. ZDV was administered as follows: 47 patients (61 per cent) received prenatal, perinatal and postnatal therapy; 13 (17 per cent) received prenatal and postnatal therapy; two (3 per cent) received prenatal and perinatal therapy; one patient received perinatal and postnatal therapy; seven (9 per cent) received only postnatal therapy. Seven HIV-1 infected women received no treatment. Thirty-two newborns were obtained by C-section (45.7 per cent), while 38 were delivered vaginally (54.2 per cent). Due to advanced maternal illness, seven HIV-1-infected women received ZDV+3TC, two women received ZDV+ddI and one woman received ZDV+3TC+ Ritonavir. Breastfeeding was avoided in all cases. Outcomes showed 65 term newborns and five preterm newborns; three abortions; one fetal loss and one preterm death. Two maternal/fetal deaths were secondar...Continue Reading

References

Oct 1, 1993·American Journal of Obstetrics and Gynecology·M K LindsayL Klein
Jul 7, 1993·JAMA : the Journal of the American Medical Association·M F Goldsmith
Jun 1, 1997·Acta Paediatrica. Supplement·P A TovoS Tulisso
Jun 5, 1998·The Pediatric Infectious Disease Journal·W J WatsonG A Weinberg
Aug 18, 1999·JAMA : the Journal of the American Medical Association·M L LindegrenP L Fleming
Aug 27, 1999·JAMA : the Journal of the American Medical Association·P G MiottiR J Biggar

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Citations

Mar 15, 2005·Infectious Diseases in Obstetrics and Gynecology·Brenna L AndersonDaniel V Landers
Aug 1, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Patrícia El Beitune, Geraldo Duarte
Jul 27, 2007·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·P El-BeituneL C Rodrigues

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