Vertical mother-to-child HIV transmission in babies born in a tertiary hospital in southern Brazil

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Manoela Muller BarbieriEdson Gomes Tristão

Abstract

Programs for the elimination of mother-to-child transmission of human immunodeficiency virus (HIV) are essentially focused on prevention actions that occur during prenatal care. This study aimed to evaluate the mother-to-child vertical transmission (MCVT) rate, and identify its possible causes, in a sample of pregnant women with HIV. This was a retrospective and descriptive study. The sample was composed of HIV-positive pregnant women who delivered a live infant in the maternity ward at the hospital of the Federal University of Parana in Brazil, between January 2007 and December 2012. The calculated MCVT rate in this study was 5.1%. Comparisons between MCVT cases and control pregnant women with HIV but without MCVT showed that the highest risk factors for MCVT were: the detection of HIV infection status only at delivery; non-attendance to high risk prenatal care; unknown viral load; and late onset of highly active antiretroviral therapy (HAART). Our results corroborate the assertion that viral replication control is essential for HAART, and that adherence to therapy is essential for such control. Factors that influence adherence to the use of antiretroviral therapy (ART) must be identified, and medical, psychological, or social...Continue Reading

References

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Sep 29, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Luiza Harunari MatidaUNKNOWN Study Group of Vertical Transmission of HIV and Syphilis
Aug 24, 2012·Reproductive Health·Maria do Carmo LealCélia Landmann Szwarcwald
Jan 3, 2013·Tropical Medicine & International Health : TM & IH·Pedro Alves da Cruz GouveiaMaria de Fatima Pessoa Militão de Albuquerque
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Apr 17, 2015·BMC Infectious Diseases·Rosa Maria Soares Madeira DominguesMaria do Carmo Leal

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Citations

Jun 6, 2020·AIDS Research and Human Retroviruses·Jiangyang ZhaoShangyang She
Jan 22, 2021·American Journal of Perinatology·Mariana MenegottoClécio H da Silva

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