Vertical transmission of SARS-CoV2 during pregnancy: A high-risk cohort.

Prenatal Diagnosis
Mariane de Fátima Yukie MaedaHC-FMUSP-Obstetric COVID19 Study Group

Abstract

Identify the potential for and risk factors of SARS-CoV-2 vertical transmission. Symptomatic pregnant women with COVID-19 diagnosis in whom PCR for SARS-CoV-2 was performed at delivery using maternal serum and at least one of the biological samples: cord blood (CB), amniotic fluid (AF), colostrum and/or oropharyngeal swab (OPS) of the neonate. The association of parameters with maternal, AF and/or CB positivity and the influence of SARS-CoV-2 positivity in AF and/or CB on neonatal outcomes were investigated. Overall 73.4% (80/109) were admitted in hospital due to COVID-19, 22.9% needed intensive care and there were four maternal deaths. Positive RT-PCR for SARS-CoV-2 was observed in 14.7% of maternal blood, 13.9% of AF, 6.7% of CB, 2.1% of colostrum and 3.7% of OPS samples. The interval between COVID-19 symptoms and delivery was inversely associated with SARS-CoV-2 positivity in the maternal blood (p = 0.002) and in the AF and/or CB (p = 0.049). Maternal viremia was associated with positivity for SARS-CoV-2 in AF and/or CB (p = 0.001). SARS-CoV-2 positivity in the compartments was not associated with neonatal outcomes. Vertical transmission is possible in pregnant women with COVID-19 and a shorter interval between maternal symp...Continue Reading

References

Nov 20, 2008·Current Protocols in Microbiology·Nicole C AmmermanAbdu F Azad
Mar 18, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cuifang FanSuqing Wang
Mar 29, 2020·American Journal of Obstetrics and Gynecology·Pradip DashraathLin Lin Su
Apr 12, 2020·Acta Obstetricia Et Gynecologica Scandinavica·Prakesh S ShahAri Bitnun
Apr 27, 2020·American Journal of Obstetrics and Gynecology·Jie YanHuixia Yang
May 14, 2020·American Journal of Perinatology·Ziyi Yang, Yi Liu
May 20, 2020·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Charles EgloffPierre Roques
May 21, 2020·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·J JuanL C Poon
May 30, 2020·Viruses·Nadin YounesGheyath K Nasrallah
Jun 10, 2020·BMJ : British Medical Journal·Marian KnightUNKNOWN UK Obstetric Surveillance System SARS-CoV-2 Infection in Pregnancy Collaborative Group
Jul 8, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·M PrabhuL E Riley
Jul 16, 2020·Nature Communications·Alexandre J VivantiDaniele De Luca
Aug 3, 2020·American Journal of Obstetrics and Gynecology·Alexander M KotlyarReshef Tal
Aug 22, 2020·JAMA : the Journal of the American Medical Association·Christina ChambersGrace Aldrovandi
Aug 23, 2020·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Silvia Figueiredo CostaEster Sabino
Sep 15, 2020·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·UNKNOWN WAPM (World Association of Perinatal Medicine) Working Group on COVID-19
Sep 28, 2020·Acta Obstetricia Et Gynecologica Scandinavica·Katarina RemaeusKarin Pettersson
Oct 14, 2020·Nature Communications·Claudio FeniziaValeria Savasi

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Software Mentioned

REDCap
Statistical Package for the Social Sciences ( SPSS

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