PMID: 11929088Apr 4, 2002Paper

Very delayed hyponatremia after surgery and radiotherapy for a pituitary macroadenoma

Journal of Endocrinological Investigation
M FilippellaA Colao

Abstract

Severe hyponatremia (118 mmol/l) with natriuresis, consistent with cerebral salt wasting syndrome (CSWS), occurred 38 days after transsphenoidal surgery in a 59-year-old woman affected by a pituitary non-functioning macroadenoma. From the 35th day after surgery, she showed progressive polyuria, hypotension and hyponatremia associated with natriuresis, decreased plasma and increased urinary osmolality. The clinical examination revealed signs of dehydration and gradual decline in the level of consciousness. The anterior pituitary function was normal due to appropriate replacement of thyroid and adrenal axis. The patient was treated with saline administration until normal natremia and water balance were restored and neurological symptoms had completely disappeared. This case focuses on the unusually prolonged time of development of post-surgery hyponatremia, despite delayed symptomatic hyponatremia being reported to commonly occur 7 days after transsphenoidal surgery. Therefore, we would advise not to limit the periodic follow-up of the hydroelectrolytic balance to the first two weeks after surgery, but to prolong it until after discharge from hospital. In fact, an early diagnosis is of great importance to prevent permanent neurol...Continue Reading

References

Dec 1, 1992·Neuroendocrinology·M C UltmannA G Robinson
Nov 1, 1990·The Journal of Laryngology and Otology·G E MurtyA R Welch
Mar 1, 1989·Journal of Endocrinological Investigation·F P CappuccioG A MacGregor
Aug 1, 1985·Annals of Neurology·E F WijdicksJ van Gijn
Oct 1, 1969·Metabolism: Clinical and Experimental·B B DavisD H Mintz
Oct 1, 1984·The American Journal of Medicine·H Al-Mufti, A I Arieff
Feb 1, 1984·Journal of Neurosurgery·P B NelsonA G Robinson
Jul 5, 1984·The New England Journal of Medicine·J F CusickJ W Findling
Jan 1, 1995·The Journal of Clinical Endocrinology and Metabolism·B R OlsonE H Oldfield
Nov 1, 1994·The Journal of Clinical Endocrinology and Metabolism·T SaneR Pelkonen
Feb 1, 1994·Neurosurgery·V SivakumarM J Chandy
Dec 1, 1993·The Journal of Clinical Endocrinology and Metabolism·K KamoiT Yamaji
Jan 1, 1996·Neurosurgery·M R Harrigan
Aug 1, 1996·Neurosurgery·B L Wise
Oct 10, 1997·Journal of Neurosurgery·B R OlsonE H Oldfield
Apr 10, 1954·Lancet·J H CORT
Apr 15, 1965·The New England Journal of Medicine·J E BETHUNE, D H NELSON

❮ Previous
Next ❯

Citations

Jan 10, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Liyun CaoQing H Meng
Jun 14, 2005·Neurological Research·Francisco R Revilla-PachecoMarcos Modiano-Esquenazi
Feb 25, 2011·Journal of Intensive Care Medicine·Urvashi M Upadhyay, William B Gormley
Jul 17, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Ann T SweeneyGeorge L Tully
Jan 9, 2015·American Journal of Therapeutics·Sunggeun LeeDonald Baumstein

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.