Very early rehabilitation or intensive telemetry after stroke: a pilot randomised trial

Cerebrovascular Diseases
Peter LanghorneCaroline Watkins

Abstract

Stroke patients are more likely to make a good recovery if they receive care in a well-organised stroke unit. However, there are uncertainties about how best to provide such care. We studied 2 key aspects of early stroke unit care: early active mobilisation (EM) and automated monitoring (AM) for physiological complications such as hypoxia. This was an observer-blinded, factorial (2 x 2) pilot randomised controlled trial recruiting stroke patients within 36 h of symptom onset. The patients were randomised to 1 of 4 nurse-led treatment protocols: (a) standard stroke unit care, (b) EM, (c) AM or (d) combined EM and AM. The primary outcome was the Rankin score at 3 months. We also report the data on feasibility and safety. We randomised 32 patients (mean age = 65 years; mean baseline modified NIH score = 6). On unadjusted comparisons, the EM patients were significantly (p < 0.05) more likely to mobilise very early (within 1 h of randomisation) and to achieve walking by day 5 and were less likely to develop complications of immobility. The AM group was significantly (p < 0.05) more likely to have pre-defined physiological complication events detected. All these associations remained, but were less statistically significant, after co...Continue Reading

Associated Clinical Trials

Citations

Dec 13, 2012·Journal of Nursing Care Quality·Beatrice J KalischSoohee Lee
Sep 12, 2013·BioMed Research International·Tanya West, Julie Bernhardt
Apr 15, 2014·Stroke Research and Treatment·Isobel J HubbardMark W Parsons
Nov 5, 2014·Neural Regeneration Research·Yurong MaoDongfeng Huang
Oct 4, 2011·Stroke Research and Treatment·Tanya West, Julie Bernhardt
Feb 18, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Torunn AskimBent Indredavik
May 18, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Antje SundsethOle Morten Rønning
Oct 2, 2012·Annales Françaises D'anesthèsie Et De Rèanimation·L OujamaaD Pérennou
Jul 24, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·YuLong BaiWenKe Fan
Jan 3, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·Julie BernhardtPeter Langhorne
Mar 20, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·Myzoon AliUNKNOWN VISTA Collaboration
Aug 21, 2012·Journal of Clinical Nursing·Ingrid G L van de PortJohanna M A Visser-Meily
Sep 14, 2013·Journal of Clinical Nursing·Beatrice J KalischBeverly W Dabney
Mar 19, 2014·International Journal of Stroke : Official Journal of the International Stroke Society·Elizabeth LynchDominique Cadilhac
Oct 6, 2014·Annals of Physical and Rehabilitation Medicine·P MarqueI Loubinoux
Aug 5, 2014·International Journal of Stroke : Official Journal of the International Stroke Society·Makoto NakajimaYukio Ando
May 28, 2013·Neurologia Medico-chirurgica·Tetsuya UebaYoshiyuki Sankai
Sep 11, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Elizabeth A LynchJulie Bernhardt
Mar 31, 2016·PloS One·Fanny HerissonUNKNOWN SEVEL study group
Jun 19, 2014·Prosthetics and Orthotics International·Bruce CarsePhilip Rowe
Jul 8, 2011·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Thalia S Field, Michael D Hill
Oct 3, 2017·Health Technology Assessment : HTA·Peter LanghorneJulie Bernhardt
Jun 4, 2013·The Cochrane Database of Systematic Reviews·Alfonso CicconeEnrico Righetti
Feb 19, 2015·Stroke; a Journal of Cerebral Circulation·Julie BernhardtToby B Cumming
Dec 17, 2014·Yonsei Medical Journal·Won Hyuk ChangYun-Hee Kim
Oct 16, 2010·Stroke; a Journal of Cerebral Circulation·Louise E CraigOlivia Wu
Jun 16, 2012·Stroke; a Journal of Cerebral Circulation·Antje SundsethOle Morten Rønning
Oct 16, 2018·The Cochrane Database of Systematic Reviews·Peter LanghorneJulie Bernhardt
Nov 28, 2018·Expert Opinion on Biological Therapy·Diego Incontri AbrahamCesar V Borlongan
Oct 17, 2019·International Journal of Nursing Practice·Ayşegül Yayla, Nadiye Özer

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