Very high-protein and low-carbohydrate enteral nutrition formula and plasma glucose control in adults with type 2 diabetes mellitus: a randomized crossover trial

Nutrition & Diabetes
Maureen B HuhmannJuan B Ochoa Gautier

Abstract

Standard enteral nutrition (EN) formulas can  worsen hyperglycemia in diabetic patients. We hypothesized that altering the proportion of macronutrients in a formula; increasing protein while decreasing carbohydrate concentrations would improve glycemic response. The objective of this study was to demonstrate that an EN formula containing a very high concentration of protein (in the form of whey peptides) and low concentration of carbohydrate provide better control of postprandial blood glucose relative to a very high-protein/higher-carbohydrate formula. This was a randomized crossover clinical trial of 12 ambulatory adult subjects with type 2 diabetes. The primary outcome was glycemic response following a bolus of isocaloric amounts of two EN formulas; the secondary outcome was insulin response. Subjects were randomized to the experimental or the control formula, on two separate days, 5-7 days apart. Mean blood glucose concentrations at 10-180 min post-infusion and mean area under the curve for glucose over 240 min post-infusion were significantly lower with the experimental formula than with the control formula (71.99 ± 595.18 and 452.62 ± 351.38, respectively; p = 0.025). There were no significant differences in the mean insu...Continue Reading

References

Mar 27, 2002·American Journal of Epidemiology·Joanne H E PromislowElizabeth Barrett-Connor
Feb 23, 2008·Journal of Rehabilitation Medicine·Wolfgang GrutherRichard Crevenna
May 13, 2008·The American Journal of Clinical Nutrition·Douglas Paddon-JonesRobert R Wolfe
May 8, 2009·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Arny A FerrandoWilliam Evans
Nov 7, 2009·The Journal of Clinical Endocrinology and Metabolism·Adam M DeaneMichael Horowitz
Jan 14, 2011·The American Journal of Clinical Nutrition·Kevin J AchesonLionel Bovetto
Mar 4, 2011·The American Journal of Clinical Nutrition·Bart PenningsLuc J C van Loon
May 25, 2013·The Journal of Clinical Endocrinology and Metabolism·Jason H Y WuDariush Mozaffarian
Jul 23, 2013·Journal of the American Medical Directors Association·Jürgen BauerYves Boirie
Apr 7, 2015·The Journal of Clinical Endocrinology and Metabolism·Jane E KerstetterKarl L Insogna
Jun 19, 2015·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Patricia DavidsonMichelle Wien
Nov 10, 2015·Critical Care : the Official Journal of the Critical Care Forum·Alfonso MesejoFátima Martinez-Lozano
Aug 17, 2016·Annals of Nutrition & Metabolism·Rachel L Adams, Kenneth Shane Broughton
Oct 22, 2016·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Yin-Yi HanRefaat A Hegazi
Jul 18, 2017·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Manpreet S MundiRyan T Hurt

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