Very low-calorie diet mimics the early beneficial effect of Roux-en-Y gastric bypass on insulin sensitivity and β-cell Function in type 2 diabetic patients

Diabetes
Clifton JacknessJ Korner

Abstract

Marked improvement in glycemic control occurs in patients with type 2 diabetes mellitus shortly after Roux-en-Y gastric bypass surgery (RYGB) and before there is major weight loss. The objective of this study was to determine whether the magnitude of this change is primarily due to caloric restriction or is unique to the surgical procedure. We studied eleven subjects who underwent RYGB and fourteen subjects mean-matched for BMI, HbA1c, and diabetes duration who were admitted to our inpatient research unit and given a very low-calorie diet (VLCD) of 500 kcal/day with a macronutrient content similar to that consumed by patients after RYGB. Frequently sampled intravenous glucose tolerance tests were performed before and after interventions. Both groups lost an equivalent amount of weight over a mean study period of 21 days. Insulin sensitivity, acute insulin secretion after intravenous glucose administration, and β-cell function as determined by disposition index improved to a similar extent in both groups. Likewise, changes in fasting glucose and fructosamine levels were similar. Based on these data, VLCD improves insulin sensitivity and β-cell function just as well as RYGB in the short term.

Associated Clinical Trials

Jul 21, 2017·Moahad S Dar

References

Mar 1, 1992·Diabetes Care·R A DeFronzoE Ferrannini
Dec 1, 1990·The Journal of Clinical Endocrinology and Metabolism·S WelchL S Phillips
Nov 1, 1985·The Journal of Clinical Endocrinology and Metabolism·R R HenryJ M Olefsky
Jun 11, 2003·Annals of Surgery·Harvey J SugermanJohn N Clore
Oct 8, 2003·Annals of Surgery·Philip R SchauerDavid Kelley
Oct 16, 2004·The Journal of Clinical Endocrinology and Metabolism·Judith KornerSharon L Wardlaw
Dec 24, 2004·The New England Journal of Medicine·Lars SjöströmUNKNOWN Swedish Obese Subjects Study Scientific Group
Oct 16, 2007·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Judith KornerJens Juul Holst
Mar 5, 2008·Current Opinion in Endocrinology, Diabetes, and Obesity·Tracy-Ann Moo, Francesco Rubino
Apr 24, 2008·The Journal of Clinical Endocrinology and Metabolism·Blandine LaferrèreBlanca Olivan
Apr 14, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·D E Cummings
May 7, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J KornerM Bessler
Dec 24, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S R KashyapP R Schauer
Mar 23, 2010·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Silas M ChikunguwoJames W Maher
May 1, 2010·Scandinavian Journal of Clinical and Laboratory Investigation·Lauri T HaltiaValtteri Kaasinen
Jun 1, 2010·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Mary DiGiorgiMarc Bessler
Aug 19, 2010·American Journal of Physiology. Endocrinology and Metabolism·Edward LinNana Gletsu-Miller
Aug 27, 2010·The Journal of Clinical Endocrinology and Metabolism·Jack L LeahyDoron Schneider
Jun 3, 2011·American Journal of Physiology. Endocrinology and Metabolism·Mark O GoodarziJerome I Rotter
Jul 23, 2011·The Journal of Clinical Endocrinology and Metabolism·M NannipieriE Ferrannini
Mar 28, 2012·The New England Journal of Medicine·Philip R SchauerDeepak L Bhatt
May 23, 2012·American Journal of Preventive Medicine·Eric A FinkelsteinWilliam Dietz
Nov 29, 2012·The Journal of Clinical Investigation·David BradleySamuel Klein

❮ Previous
Next ❯

Citations

Mar 29, 2014·Nature·Karen K RyanRandy J Seeley
Nov 6, 2014·Current Opinion in Lipidology·Peter M Clifton, Jennifer B Keogh
Aug 26, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J B SchmidtA Sjödin
Dec 24, 2015·Diabetes Care·UNKNOWN American Diabetes Association
Nov 19, 2015·Journal of Molecular Endocrinology·Sumaira Z HasnainMichael McGuckin
Oct 14, 2014·Diabetes, Obesity & Metabolism·Q-A AltafA A Tahrani
Jan 24, 2015·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·H MünzbergH-R Berthoud
Aug 29, 2016·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Steven K Malin, Sangeeta R Kashyap
May 20, 2014·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Henriette KirchnerErik Näslund
Feb 17, 2015·Diabetic Medicine : a Journal of the British Diabetic Association·S Steven, R Taylor
Mar 18, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M B MumphreyH-R Berthoud
Aug 25, 2015·Diabetology & Metabolic Syndrome·Dag HofsøJøran Hjelmesæth
Oct 23, 2015·Diabetic Medicine : a Journal of the British Diabetic Association·L RehackovaF F Sniehotta
Oct 29, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Z HaoJ Ye
Oct 29, 2013·Current Opinion in Pharmacology·Jens Juul Holst
Mar 14, 2014·The Lancet. Diabetes & Endocrinology·Sten MadsbadJens J Holst
Feb 24, 2015·Current Diabetes Reports·George Argyropoulos
Jul 22, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·B GaboritA Dutour
Dec 18, 2014·Current Opinion in Endocrinology, Diabetes, and Obesity·Maria Saur SvaneJens Juul Holst
Jul 9, 2016·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Dimitri J PournarasAnders Thorell
May 26, 2016·Diabetes Care·Rachel L Batterham, David E Cummings
Oct 1, 2016·Molecular Metabolism·Christopher D MorrisonHans-Rudolf Berthoud
Sep 3, 2016·Diabetic Medicine : a Journal of the British Diabetic Association·S StevenR Taylor
Dec 17, 2016·Diabetes Care·UNKNOWN American Diabetes Association
Mar 16, 2017·Gastrointestinal Endoscopy Clinics of North America·Lee M Kaplan
Mar 11, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·B D KayserK Clément

❮ Previous
Next ❯

Methods Mentioned

BETA
gastric bypass
ELISA

Software Mentioned

fsIVGTT
SAS
MINMOD Millennium

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.