Very low doses of heavy oxygen ion radiation induce premature ovarian failure

Reproduction : the Official Journal of the Society for the Study of Fertility
Birendra MishraUlrike Luderer

Abstract

Astronauts are exposed to charged particles during space travel, and charged particles are also used for cancer radiotherapy. Premature ovarian failure is a well-known side effect of conventional, low linear energy transfer (LET) cancer radiotherapy, but little is known about the effects of high LET charged particles on the ovary. We hypothesized that lower LET (16.5 keV/µm) oxygen particles would be less damaging to the ovary than we previously found for iron (LET = 179 keV/µm). Adult female mice were irradiated with 0, 5, 30 or 50 cGy oxygen ions or 50 cGy oxygen plus dietary supplementation with the antioxidant alpha lipoic acid (ALA). Six-hour after irradiation, percentages of ovarian follicles immunopositive for γH2AX, a marker of DNA double strand breaks, 4-HNE, a marker of oxidative lipid damage and BBC3 (PUMA), a proapoptotic BCL-2 family protein, were dose dependently increased in irradiated mice compared to controls. One week after irradiation, numbers of primordial, primary and secondary follicles per ovary were dose dependently decreased, with complete absence of follicles in the 50 cGy groups. The ED50 for primordial follicle destruction was 4.6 cGy for oxygen compared to 27.5 cGy for iron in our previous study. Se...Continue Reading

References

Nov 1, 1989·The British Journal of Radiology·W H WallaceH R Gattamaneni
Apr 20, 2001·Maturitas·I SilvaF Naftolin
Dec 1, 2001·Human Reproduction Update·D Meirow, D Nugent
Jan 15, 2003·Human Reproduction·W H B WallaceT W Kelsey
Nov 15, 2003·Annals of the ICRP·UNKNOWN Task Group on Radiation Quality Effects in Radiological Protection, Committee 1 on Radiation Effects, International Commissi
Feb 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jung H SuhTory M Hagen
Mar 26, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A Lo PrestiE Cittadini
May 12, 2004·Free Radical Biology & Medicine·Sarah G Lopez, Ulrike Luderer
Apr 28, 2005·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Julian R MolinaCharles L Loprinzi
Sep 2, 2005·Mutation Research·Chang Joo Lee, Yong-Dal Yoon
May 2, 2006·The Lancet Oncology·Francis A Cucinotta, Marco Durante
Mar 21, 2008·The Biochemical Journal·Disha DayalDouglas R Spitz
Aug 21, 2008·Menopause International·Lynne T ShusterWalter A Rocca
Feb 27, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Herman SuitAlexei Trofimov
Apr 24, 2012·Biochimica Et Biophysica Acta·Kate Petersen ShayTory M Hagen
Apr 26, 2012·BJOG : an International Journal of Obstetrics and Gynaecology·O SvejmeM K Karlsson
May 1, 2012·Cancer Letters·Jean CadetDimitar Angelov
Jan 8, 2013·Molecular Nutrition & Food Research·Luc RochetteCatherine Vergely
Nov 18, 2014·Journal of Women's Health·April E RoncaMarjorie Jenkins
Jun 27, 2015·Radiation Research·Deepa M SridharanJanice M Pluth
Aug 11, 2015·Life Sciences in Space Research·Mary Helen Barcellos-HoffMichael M Weil
Jun 3, 2016·Human Reproduction·Birendra MishraUlrike Luderer
Dec 21, 2016·Life Sciences in Space Research·Chiara La TessaAdam Rusek

❮ Previous
Next ❯

Citations

Oct 16, 2019·Nature Reviews. Endocrinology·Birendra Mishra, Ulrike Luderer
Aug 22, 2018·International Journal of Molecular Sciences·Russel J ReiterDario Acuna-Castroviejo
Aug 5, 2020·Reproductive Sciences·Renu BalaKiran Singh
Aug 28, 2020·International Journal of Radiation Biology·João Victor da Silva CoutinhoSonia Alves Gouvea
Nov 28, 2018·International Journal of Molecular Sciences·Jon G StellerApril E Ronca
Jan 8, 2021·Biology of Reproduction·Kelli F Malott, Ulrike Luderer

❮ Previous
Next ❯

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.