Very low mammographic breast density predicts poorer outcome in patients with invasive breast cancer

European Radiology
Amro MasarwahRitva Vanninen

Abstract

To examine the prognostic value of mammographic breast density (MBD) and mammographic features and their relationship with established prognostic factors in patients with invasive breast cancer. Mammographic characteristics of 270 patients were analyzed. MBD was classified according to percentile density (<5%, 5-10%, 10-25%, 25-50%, 50-75%, >75%) and further categorized into very low density (VLD; <10%), low density (LOD; <25%) and mixed density (MID; >25%). Mammographic features were compared with established prognostic factors and patient outcomes while correcting for possible confounders. MBD was inversely associated with tumour grade (p = 0.019). Patients with LOD breasts had worse prognoses compared to those with MID breasts (disease-free survival 74.7% vs. 84.8%, p = 0.048; overall survival 75.3% vs. 90.2%, p = 0.003). Patients with VLD breasts showed the strongest significance compared to the remaining patients, even after adjusting for age, body mass index, and menopausal status. No other mammographic feature was prognostically significant. In Cox regression analysis, VLD proved to be an independent, poor prognostic feature (hazard ratio = 3.275; p < 0.001). In patients with newly diagnosed breast cancer, very low MBD p...Continue Reading

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Citations

Sep 9, 2015·AJR. American Journal of Roentgenology·Stephen A Feig
Sep 13, 2015·Breast Cancer Research and Treatment·Amro MasarwahPäivi Auvinen
Oct 20, 2017·Journal of Digital Imaging·Anton NiukkanenMazen Sudah
Jun 10, 2019·Breast Cancer Research and Treatment·Michael S ShawkyErik W Thompson
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