Very low protein diet enhances inflammation, malnutrition, and vascular calcification in uremic rats

Life Sciences
Shunsuke YamadaH Ooboshi

Abstract

Clinical studies have shown that very low protein diet (VLPD) has negative effects on long-term survival. It remains unclear why VLPD induces premature death. The present study determined the underlying mechanism whereby VLPD exerts its harmful effects on uremic rats. Rats were divided into four groups and fed a normal diet or diets containing 0.3% adenine and low/normal protein with high/low phosphate. After 6weeks, body weight, urinary biochemistry (creatinine and phosphate), serum biochemical parameters (urea, creatinine, fibroblast growth factor 23, albumin, and fetuin-A), systemic inflammatory markers (serum tumor necrosis factor-alpha and urinary 8-hydroxy-2'-deoxyguanosine), calcium content in the aorta, and serum calcium-phosphate precipitates were evaluated. Hepatic mRNA levels were also determined. Rats fed the diet containing 0.3% adenine developed severe azotemia. Rats fed VLPD developed malnutrition (decreases in body weight, serum albumin and fetuin-A levels, and urinary creatinine excretion) and systemic inflammation (increases in serum tumor necrosis factor-α and urinary 8-hydroxy-2'-deoxyguanosine) independent of phosphate status. VLPD decreased the serum fetuin-A level and hepatic fetuin-A synthesis and increa...Continue Reading

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Citations

Dec 19, 2016·International Urology and Nephrology·Cristiana DavidIonel Alexandru Checherita
Sep 2, 2017·The International Journal of Biological Markers·Brian I Carr, Vito Guerra
Aug 14, 2018·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Julia B GreerDhiraj Yadav
Jun 24, 2016·American Journal of Physiology. Renal Physiology·Kun ZhangHui Huang
Feb 5, 2021·Journal of Clinical Biochemistry and Nutrition·Mariko TaniMikiko Ito
Mar 12, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Anton G KutikhinGuido Krenning

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