PMID: 11316269Apr 24, 2001Paper

Very mild exposure to hypoxia for 8 h can induce ventilatory acclimatization in humans

Pflügers Archiv : European journal of physiology
Marzieh FatemianPeter A Robbins

Abstract

Ventilatory acclimatization to altitude is associated with a progressive increase in ventilation, a progressive decrease in end-tidal PCO2 and a progressive increase in the acute ventilatory sensitivity to hypoxia. Ventilatory acclimatization has been observed with mild exposure to hypoxia when the duration of exposure has been of some length (e.g. days), and with shorter duration exposures (e.g. 8 h) when the degree of hypoxia has been more severe. The purpose of this study was to determine whether short-duration exposures to very mild hypoxia, such as are commonly associated with the reduction in cabin pressure during commercial airline flight, can also induce some degree of ventilatory acclimatization. Twelve subjects were exposed in a chamber to both 8 h mild hypoxia (inspired PO2 127 mmHg) and 8 h air-breathing as a control. Exposures were on different days in random order. Following the hypoxic exposure, there was a significant reduction in end-tidal PCO2 during air breathing (from 39.2+/-1.8 to 38.11+/-1.5 mmHg, mean +/- SD, P<0.05), and a significant increase in ventilatory sensitivity to hypoxia (from 0.84+/-0.54 l/min/% to 1.13+/-0.66 l/min/%, P<0.05). We conclude that shortterm exposures to very mild hypoxia do induc...Continue Reading

Citations

Nov 12, 2003·Respiratory Physiology & Neurobiology·Philip N AinslieMarc J Poulin
May 8, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Andrew William Sheel, Meaghan Joelle Macnutt
Feb 20, 2016·European Journal of Sport Science·Nathan E TownsendChin-Moi Chow
Aug 21, 2004·The Journal of Physiology·Sergio ReyRodrigo Iturriaga
Jan 8, 2020·BMJ Open Respiratory Research·Frances ChungUNKNOWN Op-Safe Investigators
Aug 19, 2017·Journal of Applied Physiology·Joshua L FossRobert F Chapman
Mar 27, 2018·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Ryan L HoilandPhilip N Ainslie
Sep 18, 2002·Journal of Applied Physiology·Nathan E TownsendChin-Moi Chow
Dec 14, 2004·Journal of Applied Physiology·Simon DonoghuePeter A Robbins
Dec 5, 2006·Sleep Medicine Reviews·David Wang, Harry Teichtahl

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