PMID: 6974223Sep 1, 1981Paper

Very rapid decay of mature B lymphocytes in the spleen

The Journal of Experimental Medicine
A A de Freitas, A Coutinho

Abstract

To determine the persistence of immunocompetent B lymphocytes at the periphery, regardless of cell division, we have followed the decay of lipopolysaccharide (LPS)-reactive B cells in LPS-nonresponder, histocompatible hosts. Both the numbers of transferred cells and of those persisting in the recipients could be determine with precision by limiting dilution analysis of the various cell populations. Decay rates of 50% per day were determined. Because we can exclude immune elimination of donor cells and the numbers of transferred cells were too low to result in gross alterations of the physiologic turnover rates, we conclude that the majority of LPS-reactive B lymphocytes and a large part of the whole B cell compartment show this astonishingly high rate of decay. The method introduced here might prove useful in a variety of clonal assays, as it can detect cells present at a very low frequency.

References

May 1, 1977·European Journal of Immunology·A CoutinhoT Watanabe
Aug 1, 1976·European Journal of Immunology·E GronowiczF Melchers
Sep 1, 1976·European Journal of Immunology·C J ElsonR B Taylor
Jun 1, 1969·Journal of Cellular Physiology·R G Miller, R A Phillips

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Citations

Jan 1, 1995·Immunologic Research·D F Tough, J Sprent
Jan 1, 1993·Immunology Today·A A Freitas, B B Rocha
Jan 1, 1993·Immunology Today·I MacLennan, E Chan
Jan 16, 1998·Immunology and Cell Biology·D A Fulcher, A Basten
Jul 26, 1984·The New England Journal of Medicine·F S RosenR J Wedgwood
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·I LundkvistD Holmberg
Jul 1, 1983·The Journal of Experimental Medicine·M A ThompsonM P Cancro
Jun 1, 1985·The Journal of Experimental Medicine·Y Ron, J Sprent
Oct 17, 2001·The Journal of Experimental Medicine·Z Hao, K Rajewsky
Jan 1, 1992·International Reviews of Immunology·A CoutinhoA Grandien
Jan 1, 1984·Cancer Investigation·M Potter, J F Mushinski
Jan 1, 1982·Annals of the New York Academy of Sciences·P W KincadeG Lee
Jun 1, 1986·Immunological Reviews·A A FreitasA A Coutinho
Jan 1, 1982·Immunological Reviews·P W KincadeG Lee
May 5, 1983·Nature·C Coleclough
May 1, 1995·European Journal of Immunology·E MalanchèreA Coutinho
Apr 1, 1983·European Journal of Immunology·J C BrouetJ P Cartron
Feb 1, 1987·European Journal of Immunology·M Lévy, A Coutinho
Oct 1, 1985·European Journal of Immunology·M BjörklundA Coutinho
Sep 1, 1991·European Journal of Immunology·V Thomas-VaslinA Coutinho
Nov 1, 1985·European Journal of Immunology·B Rocha
Jan 1, 1993·European Journal of Immunology·G J Deenen, F G Kroese
Sep 1, 1988·European Journal of Immunology·J H ColleA A Freitas
Aug 1, 1982·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·F H LubbeR Benner
Apr 1, 1986·Scandinavian Journal of Immunology·S KarrayA Coutinho
Feb 14, 2004·Immunological Reviews·Emmanuelle GaudinAntonio A Freitas

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