Vesicle Geometries Enabled by Dynamically Trapped States

ACS Nano
Jiaye SuMonica Olvera de la Cruz

Abstract

Understanding and controlling vesicle shapes is a fundamental challenge in biophysics and materials design. In this paper, we design dynamic protocols for enlarging the shape space of both fluid and crystalline vesicles beyond the equilibrium zone. By removing water from within the vesicle at different rates, we numerically produced a series of dynamically trapped stable vesicle shapes for both fluid and crystalline vesicles in a highly controllable fashion. In crystalline vesicles that are continuously dehydrated, simulations show the initial appearance of small flat areas over the surface of the vesicles that ultimately merge to form fewer flat faces. In this way, the vesicles transform from a fullerene-like shape into various faceted polyhedrons. We perform analytical elasticity analysis to show that these salient features are attributable to the crystalline nature of the vesicle. The potential to use dynamic protocols, such as those used in this study, to engineer vesicle shape transformations is helpful for exploiting the richness of vesicle geometries for desired applications.

References

Jan 1, 1994·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·A J Bray, A D Rutenberg
Jun 1, 1994·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·L MiaoH G Döbereiner
Jun 1, 1995·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·A D Rutenberg, A J Bray
Nov 3, 2001·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·H Noguchi, M Takasu
Apr 24, 2002·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·F Rojas, A D Rutenberg
Aug 10, 2002·Science·Dennis E Discher, Adi Eisenberg
Feb 3, 2004·TheScientificWorldJournal·Bruce N Cronstein
Oct 8, 2005·Journal of Computational Chemistry·David Van Der SpoelHerman J C Berendsen
Nov 10, 2006·The Journal of Physical Chemistry. B·A J MarkvoortP A J Hilbers
Jun 4, 2008·Physical Review Letters·Miho YanagisawaTakashi Taniguchi
Sep 17, 2008·Nature Materials·C MayerD Vlassopoulos
Jun 3, 2009·The Journal of Physical Chemistry. B·A J MarkvoortP A J Hilbers
Jun 16, 2009·Cell·Owen PornillosMark Yeager
Aug 27, 2009·Journal of the American Chemical Society·Megan A GreenfieldSamuel I Stupp
Aug 29, 2009·Journal of the American Chemical Society·Frank VersluisAlexander Kros
Mar 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Chenguang FanThomas A Bobik
Mar 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Graziano VernizziMonica Olvera de la Cruz
Mar 18, 2011·Angewandte Chemie·Christophe B MinkenbergJan H van Esch
Jun 28, 2011·Physical Review Letters·Rastko SknepnekMonica Olvera de la Cruz
Mar 21, 2012·Proceedings of the National Academy of Sciences of the United States of America·Xiangjun XingMin-Hui Li
Sep 26, 2012·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Rastko Sknepnek, Monica Olvera de la Cruz
Oct 4, 2012·Physical Review Letters·Sujit S DattaDavid A Weitz
Nov 29, 2012·ACS Nano·Cheuk-Yui LeungMonica Olvera de la Cruz
Feb 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Linda S HirstRobin L B Selinger
Sep 26, 2013·Proceedings of the National Academy of Sciences of the United States of America·Cheuk-Yui LeungMichael J Bedzyk
Oct 1, 2013·Physical Review Letters·Zhenwei Yao, Monica Olvera de la Cruz
Nov 12, 2013·Physical Review Letters·Ee Hou YongL Mahadevan
Jun 14, 2014·General and Comparative Endocrinology·Ketki V Deshpande, Arun G Jadhao
May 1, 2008·Journal of Chemical Theory and Computation·Luca MonticelliSiewert-Jan Marrink

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Citations

Jun 21, 2017·Soft Matter·Pardis RofouieAlejandro D Rey
Jun 3, 2017·The Journal of Chemical Physics·Jiaye SuYue Shi
Apr 19, 2019·Chemical Science·Chin Ken WongPall Thordarson

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