Vesicular accumulation of dopamine following L-DOPA administration

Biochemical Pharmacology
N T Buu

Abstract

In this study, the accumulations of dopamine (DA) and norepinephrine (NE) were measured in the brain tissues and in the synaptic vesicle fractions prepared from whole brain of control rats and rats injected with L-DOPA. In the normal rat brain, a 3-fold increase in DA following L-DOPA administration was followed by a small, but not significant increase in vesicular DA, indicating a restricted vesicular uptake of exogenous DA. At the same time, NE in the vesicular fraction and in the whole brain tissue did not change, suggesting a possible link between DA vesicular uptake of DA and brain NE. However, in rats pretreated with alpha-methyl-p-tyrosine, which significantly (P less than 0.05) reduced DA and NE levels in brain tissues and in the synaptic vesicles, L-DOPA administration led to a significant increase in vesicular DA (P less than 0.05), suggesting that catecholamine depletion may result in greater vesicular uptake of cytoplasmic DA. The increase in vesicular DA was accompanied by increases in tissue and vesicular NE, underscoring again the existence of a link between vesicular uptake of DA and brain NE following L-DOPA administration. The results also demonstrated a large increase in 3,4-dihydroxyphenylacetic acid (DOPAC)...Continue Reading

References

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Citations

May 21, 2009·Journal of Inherited Metabolic Disease·Wang-Tso LeeKai-Yuan Tzen
May 1, 2009·Behavioural Pharmacology·Yusuke KabukiMitsuhiro Furuse
Nov 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Emanuela MorelliMark S Ansorge
Feb 1, 1990·Journal of Neurochemistry·N T Buu, W Debinski
Feb 4, 2010·Nuclear Medicine and Biology·Michael R KilbournKirk A Frey
Aug 8, 2006·European Journal of Pharmacology·Naila IsmayilovaMichael J Dascombe
Mar 16, 2000·Reviews in the Neurosciences·D Sulzer, E N Pothos

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