Vesicular accumulation of dopamine following L-DOPA administration

Biochemical Pharmacology
N T Buu


In this study, the accumulations of dopamine (DA) and norepinephrine (NE) were measured in the brain tissues and in the synaptic vesicle fractions prepared from whole brain of control rats and rats injected with L-DOPA. In the normal rat brain, a 3-fold increase in DA following L-DOPA administration was followed by a small, but not significant increase in vesicular DA, indicating a restricted vesicular uptake of exogenous DA. At the same time, NE in the vesicular fraction and in the whole brain tissue did not change, suggesting a possible link between DA vesicular uptake of DA and brain NE. However, in rats pretreated with alpha-methyl-p-tyrosine, which significantly (P less than 0.05) reduced DA and NE levels in brain tissues and in the synaptic vesicles, L-DOPA administration led to a significant increase in vesicular DA (P less than 0.05), suggesting that catecholamine depletion may result in greater vesicular uptake of cytoplasmic DA. The increase in vesicular DA was accompanied by increases in tissue and vesicular NE, underscoring again the existence of a link between vesicular uptake of DA and brain NE following L-DOPA administration. The results also demonstrated a large increase in 3,4-dihydroxyphenylacetic acid (DOPAC)...Continue Reading


Mar 15, 1975·Biochemical Pharmacology·G Powis
Nov 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·A Alousi, N Weiner
Jul 1, 1974·Clinical and Experimental Pharmacology & Physiology·W J LouisR G Sampson
Oct 1, 1974·Life Sciences·O Hornykiewicz
Jul 1, 1972·Neurology·L K NgI J Kopin
Jun 1, 1984·Journal of Neurochemistry·J W Commissiong

❮ Previous
Next ❯


May 21, 2009·Journal of Inherited Metabolic Disease·Wang-Tso LeeKai-Yuan Tzen
May 1, 2009·Behavioural Pharmacology·Yusuke KabukiMitsuhiro Furuse
Nov 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Emanuela MorelliMark S Ansorge
Feb 1, 1990·Journal of Neurochemistry·N T Buu, W Debinski
Feb 4, 2010·Nuclear Medicine and Biology·Michael R KilbournKirk A Frey
Aug 8, 2006·European Journal of Pharmacology·Naila IsmayilovaMichael J Dascombe
Mar 16, 2000·Reviews in the Neurosciences·D Sulzer, E N Pothos

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.