Vesicular-Bound HLA-G as a Predictive Marker for Disease Progression in Epithelial Ovarian Cancer

Cancers
Esther SchwichPaul Buderath

Abstract

Extracellular vesicles (EV) and their tumor-supporting cargos provide a promising translational potential in liquid biopsies for risk assessment of epithelial ovarian cancer (EOC) patients frequently relapsing, despite initial complete therapy responses. As the immune checkpoint molecule HLA-G, which is operative in immune-escape, can be released by EV, we evaluate the abundance of EV and its vesicular-bound amount of HLA-G (HLA-GEV) as a biomarker in EOC. After enrichment of EV from plasma samples, we determined the EV particle number and amount of HLA-GEV by nanoparticle tracking analysis or ELISA. The association of results with the clinical status/outcome revealed that both, EV particle number and HLA-GEV were significantly elevated in EOC patients, compared to healthy females. However, elevated levels of HLA-GEV, but not EV numbers, were exclusively associated with a disadvantageous clinical status/outcome, including residual tumor, presence of circulating tumor cells, and disease progression. High HLA-GEV status was an independent predictor of progression, besides residual tumor burden and platinum-sensitivity. Especially among patients without residual tumor burden or with platinum-sensitivity, HLA-GEV identified patient...Continue Reading

References

May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·P PaulE D Carosella
Aug 3, 2002·Nature Reviews. Immunology·Clotilde ThérySebastian Amigorena
Nov 7, 2003·Human Immunology·Vera RebmannHans Grosse-Wilde
Dec 31, 2003·Biochemical and Biophysical Research Communications·Gyu Man ParkKwangseog Ahn
Jan 8, 2004·Seminars in Cancer Biology·Vera RebmannHans Grosse-Wilde
Oct 12, 2005·Human Immunology·Vera RebmannHans Grosse-Wilde
Apr 21, 2007·Tissue Antigens·V RebmannH Grosse-Wilde
Feb 6, 2008·Trends in Immunology·Edgardo D CarosellaNathalie Rouas-Freiss
Mar 13, 2008·Blood·Edgardo D CarosellaJoel Lemaoult
Sep 27, 2008·Human Immunology·Edgardo D CarosellaJoel LeMaoult
Nov 10, 2009·Current Biology : CB·Vandhana Muralidharan-ChariCrislyn D'Souza-Schorey
Nov 11, 2010·Cellular and Molecular Life Sciences : CMLS·Laurence AmiotBarbara Seliger
Apr 12, 2011·Cancer Research·Joshua L HoodSamuel A Wickline
Apr 28, 2011·CA: a Cancer Journal for Clinicians·Danijela Jelovac, Deborah K Armstrong
May 12, 2011·Cellular and Molecular Life Sciences : CMLS·Bence GyörgyEdit I Buzás
Jun 7, 2011·Colloids and Surfaces. B, Biointerfaces·Viktoriya SokolovaBernd Giebel
Sep 2, 2011·Kidney International·Bas W M van BalkomMark A Knepper
Apr 28, 2012·Critical Reviews in Clinical Laboratory Sciences·Alvaro GonzálezEstibaliz Alegre
Nov 2, 2012·Nephrology·Doreen Yp FangJonathan M Gleadle
Feb 20, 2013·The Journal of Cell Biology·Graça Raposo, Willem Stoorvogel
Apr 26, 2013·International Journal of Cancer. Journal International Du Cancer·Kornelius SchulzeHenning Wege
May 7, 2014·Journal of Immunology Research·Nathalie Rouas-FreissEdgardo D Carosella
Jul 6, 2014·Journal of Immunology Research·M J RuttenE S Jordanova
Sep 10, 2014·Cancers·Genevieve HousmanSibaji Sarkar
Nov 19, 2014·Nature Reviews. Urology·Muhammad NawazThomas Kislinger
Feb 20, 2015·TheScientificWorldJournal·Jin LinXiao-Zhong Wang
May 17, 2015·Journal of Extracellular Vesicles·María Yáñez-MóOlivier De Wever
Nov 3, 2016·Nature Reviews. Clinical Oncology·Malte MohmeKlaus Pantel
Jul 29, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Lydia GiannopoulouEvi S Lianidou
Apr 2, 2018·Human Immunology·Alexander A CelikChristina Bade-Döding
Apr 11, 2018·Frontiers in Immunology·Esther Schwich, Vera Rebmann
Apr 4, 2019·Molecular Cancer·Ladan MashouriSuresh K Alahari

❮ Previous
Next ❯

Citations

May 13, 2020·Advanced Biosystems·Scott Ferguson, Ralph Weissleder
Sep 15, 2020·Frontiers in Immunology·Maria LoustauJulien Caumartin
Jul 18, 2021·HLA : Immune Response Genetics·Wafa BabayInès Zidi

❮ Previous
Next ❯

Methods Mentioned

BETA
blood collection

Software Mentioned

SPSS
BIAS
R package survminer
GraphPad Prism

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.