Vesicular glutamate transporter 3 (VGLUT3) identifies spatially segregated excitatory terminals in the rat substantia nigra

The European Journal of Neuroscience
Raquel Martín-IbañezTibor Harkany

Abstract

The excitability of dopaminergic (DA) neurons in the substantia nigra is controlled by the convergent activity of multiple glutamatergic afferents. Here, we show that vesicular glutamate transporter 3 (VGLUT3)-immunoreactive (ir) terminals segregate to the perisomatic region of DA neurons in the substantia nigra pars compacta, and VGLUT3 decorates a synapse population distinct from those marked by vesicular glutamate transporters 1 and 2. VGLUT3-ir nerve endings form asymmetric terminals on DA neurons. Retrograde tracing suggests the superior colliculus as an origin of excitatory VGLUT3-ir afferents. Collectively, our data indicate that VGLUT3 identifies a novel excitatory terminal subset that contributes to the tuning of DA cell excitability in the substantia nigra.

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Citations

Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jan MulderTibor Harkany
Dec 25, 2008·The Journal of Comparative Neurology·Sergueï O FetissovTomas Hökfelt
Nov 22, 2011·The Journal of Comparative Neurology·Alexis LauxYannick Goumon
Oct 23, 2010·Glia·Carina HalleskogGunnar Schulte
May 6, 2016·Frontiers in Neuroanatomy·Aurore N VoisinLouis-Éric Trudeau
Mar 19, 2011·Nature Reviews. Neuroscience·Salah El MestikawyLouis-Eric Trudeau
Dec 5, 2019·Proceedings of the National Academy of Sciences of the United States of America·Janos FuzikTibor Harkany

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