PMID: 7539506Jul 1, 1995Paper

Vesicular stomatitis virus infection induces a nuclear DNA-binding factor specific for the interferon-stimulated response element

Journal of Virology
C BovolentaK Ozato

Abstract

Vesicular stomatitis virus (VSV) has a broad host range. It replicates in the cytoplasm and causes rapid cytopathic effects. We show that following VSV infection, a nuclear factor that binds to a select set of interferon-stimulated responsive elements (ISRE) is induced in many cell types. This factor, tentatively called VSV-induced binding protein (VIBP), was estimated to have an approximate molecular mass of 50 kDa and was distinct from known members of the interferon regulatory factor family, that are known to bind to the ISRE. Induction of VIBP required tyrosine kinase activity but did not require cellular transcription. Treatment of cells with cycloheximide, which inhibits translation, only partially inhibited induction of VIBP. However, type I interferons and staurosporine, both of which inhibit VSV transcription, inhibited VIBP induction. Moreover, a double-stranded RNA analog, poly(I)-poly(C) also induced a DNA-binding activity very similar to that of VIBP. These results indicate that a preexisting cellular protein is activated upon VSV infection and that this activation requires primary viral transcripts. The functional activity of VIBP was analyzed in cells stably transfected with a herpesvirus thymidine kinase-lucifer...Continue Reading

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Citations

Feb 16, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Marc J ServantRongtuan Lin
Aug 3, 1999·The Journal of Experimental Medicine·L GabrieleH C Morse
Apr 1, 1997·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·R MarienfeldC Jungwirth
Apr 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Kristi L PetersGanes C Sen
Jun 29, 1999·Cold Spring Harbor Symposia on Quantitative Biology·T ManiatisM G Wathelet
Dec 19, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M BehrC Jungwirth

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