PMID: 7545248Oct 1, 1995Paper

Vesicular stomatitis virus infection of the central nervous system activates both innate and acquired immunity

Journal of Virology
Z BiC S Reiss

Abstract

Vesicular stomatitis virus (VSV) causes acute infection of the central nervous system (CNS) when intranasally applied. We have examined cellular inflammatory changes in the CNS following VSV infection. As early as 1 day postinfection (p.i.), astrocytes were activated in the olfactory bulb (OB). This was followed by activation of microglia, first observed in the OB at day 3 p.i. Expression of inducible nitric oxide synthase was observed in activated microglia in the OB at day 3 p.i., and increased inducible nitric oxide synthase expression coincided with decreased virus titers in tissue homogenates. Expression of major histocompatibility complex (MHC) class I molecules on astrocytes and microglial, endothelial, and ependymal cells was also rapidly induced and followed by induced expression of MHC class II molecules on astrocytes and microglial and endothelial cells. Consistent with the pattern of viral dissemination, MHC molecules were expressed temporally from the rostral-to-caudal direction. Infiltration of CD8+ cells was observed as early as 1 day p.i. in the OB. CD4+ cells were detected in the OB at day 4 p.i. Increasing T-cell infiltration coincided with decreased virus titers. In contrast, B-cell infiltration of the CNS wa...Continue Reading

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Citations

Oct 31, 1996·Annals of the New York Academy of Sciences·C S ReissZ Bi
Oct 23, 1998·Journal of Drug Targeting·S MathisonU B Kompella
Mar 16, 2005·Journal of Virology·J D RempelD L Gruol
Nov 13, 2009·Journal of Virology·Elizabeth J KellyStephen J Russell
Oct 12, 2012·The Journal of General Virology·Eric Hastie, Valery Z Grdzelishvili
Sep 14, 2013·Cancer Gene Therapy·D Escobar-ZarateK-W Peng
Dec 3, 1999·Immunology·F Benencia, M C Courreges
May 3, 2003·Viral Immunology·David A CheslerCarol Shoshkes Reiss
Apr 5, 2012·Proceedings of the National Academy of Sciences of the United States of America·Paul M D'AgostinoKaren Bulloch
Jun 20, 2020·Chemical Senses·Albert Y HanIvan A Lopez
Oct 6, 2006·Journal of Virology·Mikhail V OvanesovMikhail V Pletnikov
Jan 27, 2005·Viral Immunology·Glen N Barber
Jun 26, 2002·Viral Immunology·Nannan Chen, Carol Shoshkes Reiss
Sep 4, 2009·Journal of Virology·Koray OzdumanAnthony N van den Pol
May 23, 2012·PLoS Pathogens·Volker FensterlGanes C Sen
Sep 3, 2011·Microbiology and Molecular Biology Reviews : MMBR·Denis Gerlier, Douglas S Lyles
May 20, 2015·The European Journal of Neuroscience·Aline A de SousaCristovam Wanderley P Diniz
Aug 14, 2013·Clinical and Experimental Immunology·Gail D SckiselWilliam J Murphy
Dec 23, 2016·Oxidative Medicine and Cellular Longevity·Nara LinsCristovam Wanderley Picanço-Diniz
Jun 7, 2020·Science Immunology·E Ashley MosemanDorian B McGavern
Feb 26, 2004·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·David A CheslerCarol Shoshkes Reiss
Jan 1, 1997·Viral Immunology·T KomatsuC S Reiss
May 4, 2004·Journal of Medical Virology·Gisela GambaFabian Benencia
Feb 4, 1999·Annals of the New York Academy of Sciences·C S ReissT Komatsu
Feb 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claudia N DetjeUlrich Kalinke

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