PMID: 9433126Jan 20, 1998Paper

Vesicular transport: how many Ypt/Rab-GTPases make a eukaryotic cell?

Trends in Biochemical Sciences
T LazarD Gallwitz

Abstract

In eukaryotic cells, protein transport through the secretory and endocytic pathways is mediated by vesicular intermediates. Individual transport steps are regulated by Ras-like guanine nucleotide-binding proteins, termed Ypt in yeast or Rab in mammals. The complete sequencing of the Saccharomyces cerevisiae genome has revealed the total number of Ypt GTPases in this organism. There is some redundancy among the 11 Ypt proteins, and only those involved in the biosynthetic pathway are essential for cell viability.

References

Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·I S SigalE M Scolnick
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·N TouchotA Tavitian
Jan 1, 1994·Annual Review of Biochemistry·M K Bennett, R H Scheller
Dec 15, 1994·Nature·J P LianS Ferro-Novick
Jun 1, 1993·Molecular Biology of the Cell·J ArmstrongS Bowden
Apr 12, 1996·Science·J E Rothman, F T Wieland
Nov 1, 1996·The Journal of Cell Biology·O UllrichR G Parton
May 8, 1997·Nature·B J NicholsA Haas
Dec 1, 1996·Trends in Cell Biology·S Y BednarekR Schekman

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Citations

Jul 13, 2000·Biochemical and Biophysical Research Communications·R AdachiB F Dickey
Nov 7, 2008·Protoplasma·M Götte, T Lazar
Apr 17, 2009·Cell and Tissue Research·Tanmay Bhuin, Jagat K Roy
Oct 18, 2003·Molecular and Biochemical Parasitology·Jude M PrzyborskiMichael Lanzer
Jul 17, 2001·Current Opinion in Cell Biology·N Segev
Oct 3, 2002·Protein Expression and Purification·Vadim SidorovitchKirill Alexandrov
Jun 8, 2002·Fungal Genetics and Biology : FG & B·Gagan D Gupta, I Brent Heath
Oct 24, 2002·Current Opinion in Plant Biology·Stephen Rutherford, Ian Moore
Aug 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ryan M Nottingham, Suzanne R Pfeffer
May 5, 2007·Journal of Toxicology and Environmental Health. Part a·Chun-Ping LiJian-Wei Zhou
Sep 11, 2002·Molecular Biology of the Cell·Wei Wang, Susan Ferro-Novick
Oct 8, 1999·Molecular Biology of the Cell·M Spaargaren, J L Bos
Dec 10, 1999·Molecular Biology of the Cell·E Grote, P J Novick
Jun 8, 1999·Molecular Biology of the Cell·G Fischer von Mollard, T H Stevens
Jun 13, 2003·Molecular Biology of the Cell·Monica CaleroRuth N Collins
Jan 14, 2005·Molecular Biology of the Cell·Allison ZajacWei Guo
Sep 16, 2000·The EMBO Journal·S SiniossoglouH R Pelham
Dec 16, 2000·The EMBO Journal·G EitzenW Wickner
Oct 13, 2001·The EMBO Journal·O MüllerA Mayer
Feb 18, 2004·Molecular Plant-microbe Interactions : MPMI·Tomas JohanssonAnders Tunlid
Mar 20, 2003·Plant Physiology·Vanessa VernoudErik Nielsen
Mar 3, 2006·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Aymelt ItzenAlexey Rak
May 5, 2005·Applied and Environmental Microbiology·Andrew H SimsGeoffrey D Robson

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