PMID: 9420657Jun 1, 1995Paper

Vesnarinone: a new inotropic agent for treating congestive heart failure

Journal of Cardiac Failure
E CavusogluM Klapholz

Abstract

Vesnarinone is a new and novel inotropic drug that has unique and complex mechanisms of action. It inhibits phosphodiesterase, thereby leading to increased intracellular calcium, and also affects numerous myocardial ion channels, resulting in the prolongation of the opening time of sodium channels and the decrease in the delayed outward and inward rectifying potassium current. In vitro, it has also demonstrated significant effects on cytokine production, which may account for some of its observed clinical benefits. Hemodynamic studies in humans with congestive heart failure reveal that vesnarinone can improve ventricular function. Placebo-controlled studies in large numbers of patients with heart failure have suggested a morbidity and mortality benefit with a 60 mg daily dose. There is increased mortality with vesnarinone at the 120 mg daily dose, however, suggesting a narrow therapeutic window for the drug. Its predominant toxic side effect is a 2% incidence of reversible neutropenia.

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Citations

Feb 1, 2003·European Journal of Heart Failure·Barry GreenbergSergio Perrone
Sep 1, 1996·Journal of Cardiac Failure·S Sasayama, A Matsumori
Dec 1, 1995·Journal of Cardiac Failure·S Sasayama
Aug 6, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Shigetake Sasayama
Aug 14, 2019·European Journal of Heart Failure·Tariq AhmadJoann Lindenfeld
Feb 9, 2013·Molecular Pharmacology·Kentaro HottaHiroshi Handa
Feb 24, 2021·Bioorganic Chemistry·Pratibha Yadav, Kamal Shah

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