Vessel counts and vascular endothelial growth factor expression in pancreatic adenocarcinoma

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
L M EllisD B Evans

Abstract

Angiogenesis is essential for growth and metastasis of solid malignancies. In several tumours, tumour vessel count and expression of vascular endothelial growth factor (VEGF), a potent angiogenic factor, have been associated with prognosis. To determine if vessel count and VEGF expression are prognostic factors in pancreatic cancer, we examined these parameters in resected tumour specimens from 22 patients who did not receive pre-operative therapy. Paraffin-embedded tumour specimens were immunohistochemically stained for factor VIII (surrogate for vessels) and VEGF. Vessel counts and VEGF expression were evaluated without knowledge of patient outcome. The median follow-up for the entire group had not been reached as of 23.1 months (range 10-69 months). The mean vessel count and VEGF expression were no different between those patients who had recurrences and those who did not. By linear regression analysis, the correlation of VEGF expression with vessel count did not reach statistical significance (P = 0.0685). Survival and time to recurrence were similar in patients with high and low vessel counts and VEGF expression of 1, 2 or 3. Tumour differentiation or lymph node positivity had no effect on either VEGF expression or vessel ...Continue Reading

References

Jan 3, 1991·The New England Journal of Medicine·N WeidnerJ Folkman
Jan 1, 1995·Oncology·M OhsawaK Aozasa
Apr 21, 1995·International Journal of Cancer. Journal International Du Cancer·M ToiT Tominaga
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·S Y ChengW K Cavenee
Dec 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L M Ellis, I J Fidler

❮ Previous
Next ❯

Citations

Aug 2, 2008·Journal of Hepato-biliary-pancreatic Surgery·Kenji TakagiIchirou Takahashi
Jun 18, 2005·Biochemical and Biophysical Research Communications·Napoleone FerraraWilliam Novotny
Oct 1, 2003·Gastroenterology·Anne-Marie Marion-AudibertJean-Yves Scoazec
Nov 24, 2001·Surgical Oncology·C J MageeJ P Neoptolemos
Mar 15, 2001·Critical Reviews in Oncology/hematology·H H Sedlacek
May 12, 2004·Nature Reviews. Drug Discovery·Napoleone FerraraWilliam Novotny
Mar 19, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Hiroyuki KumamotoKiyoshi Ooya
Dec 27, 2007·Cancer Biotherapy & Radiopharmaceuticals·Wei LvPei-Wu Yu
Apr 27, 2010·Pancreas·Emily L DeerSean J Mulvihill
Sep 13, 2006·Gut·J HeidemannT Kucharzik
Aug 17, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christine FeigDavid A Tuveson
Jul 18, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·K KiehneK H Herzig
Jul 18, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·T KeckS González
Feb 27, 2007·Vascular Health and Risk Management·Roberta W C Pang, Ronnie T P Poon
Jun 27, 2013·Journal of Hepato-biliary-pancreatic Sciences·Yoichiro MatsuoSonshin Takao
Oct 11, 2008·Ultrasound in Medicine & Biology·Mutsumi NishidaMasato Hareyama
Dec 20, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Roy M BremnesRafael Sirera
Jun 18, 2002·Hematology/oncology Clinics of North America·Robert A Wolff
Aug 23, 2006·ANZ Journal of Surgery·Giuseppe GarceaDavid P Berry
Sep 27, 2002·The Korean Journal of Internal Medicine·Young Eun JooSei Jong Kim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.