Vessel density assessed by endoglin expression in breast carcinomas with different expression profiles

Histopathology
Nair LopesFernando Schmitt

Abstract

To evaluate the relationship between microvessel density assessed by endoglin expression and the molecular subtypes of human invasive breast carcinomas and whether there is evidence to indicate that angiogenesis could be a putative target for therapy in specific subsets of breast cancer. We studied a series of 161 breast carcinomas, but information was available on only 142 tumours. We correlated endoglin expression with distinct breast carcinoma subgroups classified according to immunohistochemical profiling. Additionally, we compared it with other biomarkers for the aggressive basal-like subset and with available histopathological data. Although the basal-like subtype has higher microvessel density, there are no significant differences with the other molecular subtypes of breast cancer. This study found no significant differences in tumour vascularity in different molecular subtypes of breast cancer.

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Citations

Aug 30, 2011·Breast Cancer Research and Treatment·Hawa NalwogaLars A Akslen
Sep 15, 2011·PloS One·Valgardur SigurdssonThorarinn Gudjonsson
Mar 9, 2012·Pathology, Research and Practice·Li Qin LiLi Cheng Dai
Jan 7, 2011·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Li Qin LiLi Cheng Dai
Mar 13, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Tuenjai ChuangsuwanichDoonyapat Sa-Nguanraksa
Oct 31, 2015·PloS One·Gabriele BonaventuraMaria Luisa Barcellona
Nov 26, 2011·Oncology·Piotr K ZakrzewskiWanda M Krajewska
Nov 26, 2010·Virchows Archiv : an International Journal of Pathology·Minoru MiyashitaHironobu Sasano
Dec 4, 2012·Oncology Letters·Marta TiburcioAdhemar Longatto Filho

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