Vestibular control of sympathetic activity. An otolith-sympathetic reflex in humans

Experimental Brain Research
H KaufmannB Cohen

Abstract

It has been proposed that a vestibular reflex originating in the otolith organs and other body graviceptors modulates sympathetic activity during changes in posture with regard to gravity. To test this hypothesis, we selectively stimulated otolith and body graviceptors sinusoidally along different head axes in the coronal plane with off-vertical axis rotation (OVAR) and recorded sympathetic efferent activity in the peroneal nerve (muscle sympathetic nerve activity, MSNA), blood pressure, heart rate, and respiratory rate. All parameters were entrained during OVAR at the frequency of rotation, with MSNA increasing in nose-up positions during forward linear acceleration and decreasing when nose-down. MSNA was correlated closely with blood pressure when subjects were within +/-90 degrees of nose-down positions with a delay of 1.4 s, the normal latency of baroreflex-driven changes in MSNA. Thus, in the nose-down position, MSNA was probably driven by baroreflex afferents. In contrast, when subjects were within +/-45 degrees of the nose-up position, i.e., when positive linear acceleration was maximal along the naso-ocipital axis, MSNA was closely related to gravitational acceleration at a latency of 0.4 s. This delay is too short for ...Continue Reading

Citations

Nov 26, 2005·Experimental Brain Research·Andrei VoustianioukBernard Cohen
May 25, 2006·Experimental Brain Research·Leah R BentVaughan G Macefield
Mar 5, 2011·Experimental Brain Research·Bernard CohenSergei B Yakushin
Dec 30, 2011·Experimental Brain Research·Mitsuhiro AokiYatsuji Ito
Oct 13, 2009·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Matteo PezzoliRoberto Albera
Apr 20, 2005·Acta Astronautica·Steven T MooreBernard Cohen
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