Vestibular damage in chronic ototoxicity: a mini-review

Neurotoxicology
Lara Sedó-CabezónJordi Llorens

Abstract

Ototoxicity is a major cause of the loss of hearing and balance in humans. Ototoxic compounds include pharmaceuticals such as aminoglycoside antibiotics, anti-malarial drugs, loop diuretics and chemotherapeutic platinum agents, and industrial chemicals including several solvents and nitriles. Human and rodent data indicate that the main target of toxicity is hair cells (HCs), which are the mechanosensory cells responsible for sensory transduction in both the auditory and the vestibular system. Nevertheless, the compounds may also affect the auditory and vestibular ganglion neurons. Exposure to ototoxic compounds has been found to cause HC apoptosis, HC necrosis, and damage to the afferent terminals, of differing severity depending on the ototoxicity model. One major pathway frequently involved in HC apoptosis is the c-jun N-terminal kinase (JNK) signaling pathway activated by reactive oxygen species, but other apoptotic pathways can also play a role in ototoxicity. Moreover, little is known about the effects of chronic low-dose exposure. In rodent vestibular epithelia, extrusion of live HCs from the sensory epithelium may be the predominant form of cell demise during chronic ototoxicity. In addition, greater involvement of the ...Continue Reading

References

Apr 1, 1992·Neuroreport·R PujolM Eybalin
Sep 1, 1987·The Journal of Infectious Diseases·R Hinojosa, S A Lerner
Aug 22, 1983·Brain Research·D W Jensen
May 8, 1995·The Journal of Comparative Neurology·L LiA Forge
Jan 1, 1997·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·T NakagawaY Nakai
Mar 1, 1997·Neurotoxicology and Teratology·J Llorens, E Rodríguez-Farré
Jan 23, 1999·Current Opinion in Cell Biology·T S StappenbeckJ I Gordon
Apr 2, 1999·Trends in Pharmacological Sciences·P NicoteraL Manzo
Sep 25, 2001·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·F O BlackS C Pesznecker
May 29, 2002·Hearing Research·Benoît PouyatosRobert Lataye
Nov 16, 2002·Hearing Research·Sandra L McFaddenRichard J Salvi
Jan 30, 2004·The Journal of Comparative Neurology·Keiko HiroseEdwin W Rubel
Jun 4, 2004·The Journal of Comparative Neurology·Dominic A MangiardiDouglas A Cotanche
Jul 9, 2004·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·F Owen BlackValerie Stallings
Aug 10, 2004·The Journal of Comparative Neurology·Sabine LadrechMarc Lenoir
Sep 25, 2004·Journal of Neurobiology·Jonathan I MatsuiMark E Warchol
Feb 22, 2005·Hearing Research·Carol A Bauer, Thomas J Brozoski
Jul 16, 2005·Cell Death and Differentiation·H JiangJ Schacht
Oct 11, 2005·Drug Discovery Today·Leonard P Rybak, Craig A Whitworth
Nov 12, 2005·Current Opinion in Otolaryngology & Head and Neck Surgery·Alan G ChengEdwin W Rubel
Apr 14, 2006·Expert Opinion on Drug Safety·Joshua G YorgasonFederico Kalinec
Sep 19, 2006·Hearing Research·Dalian DingRichard Salvi
Dec 13, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Carla Soler-MartínJordi Llorens

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Citations

Dec 2, 2015·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Arzu TatarAbdulgani Tatar
Oct 25, 2016·The Laryngoscope·Nicole Tin-Lok JiamYuri Agrawal
Apr 15, 2015·Journal of Pharmacokinetics and Pharmacodynamics·Tarjinder SahotaOscar Della Pasqua
Oct 25, 2016·Toxicology Letters·Yasumitsu TakimotoShoichi Shimada
Jan 15, 2017·Hearing Research·M Charles Liberman, Sharon G Kujawa
Jul 27, 2018·The Journal of Laryngology and Otology·K GraydonH Gunasekera
Aug 31, 2017·Journal of Biomedical Optics·Min Young LeeChung Ku Rhee
Nov 17, 2015·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Shin KariyaSebahattin Cureoglu
Jul 19, 2019·Experimental and Therapeutic Medicine·Lukas HorvathArianne Monge Naldi
Jan 6, 2017·ILAR Journal·Kevin Strange
Feb 12, 2019·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Sayan MannaGeorge Wanna
Apr 23, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Xiaoyi YuanChunxin Fan
May 1, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Dongjuan XuAlexander L Francis
Jul 25, 2021·Otolaryngologic Clinics of North America·Christine LittleMaura K Cosetti

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