PMID: 15219045Jun 29, 2004Paper

Vestibular destruction by slow infusion of gentamicin into semicircular canals

Acta Oto-laryngologica. Supplementum
Ming LiiRichard J Salvi

Abstract

Intratympanic or round window application of gentamicin is often used to alleviate disabling vertigo arising from unilateral Meniere's disease; however, treatment is often accompanied by hearing loss because the drug initially enters the cochlea before diffusing to the vestibular system. In order to enhance vestibular damage and reduce the risk of hearing loss, gentamicin was infused directly into the vestibular system. An osmotic pump containing 50, 100, 200 or 400 microg/ml of gentamicin was infused into the superior semicircular canal of the chinchilla for 7 days. Afterwards, vestibular damage was evaluated by measuring the decline in hair cell density in the utricle, saccule and superior semicircular canals. Auditory damage was assessed with distortion product otoacoustic emissions (DPOAE) and outer hair cell (OHC) and inner hair cell (IHC) loss. Infusion with the two lowest gentamicin concentrations resulted in significant hair cell loss and reduced duration of the nystagmus response, but had little or no effect on OHC or DPOAE. Higher doses of gentamicin damaged cochlear hair cells and reduced the DPOAE. In conclusion, slow infusion of a low dose of gentamicin into the semicircular canals mainly damages the vestibular hai...Continue Reading

Citations

Apr 21, 2009·Journal of Neurology·Bernhard BaierM Dieterich
Oct 26, 2011·Toxicology and Applied Pharmacology·G VignauxS Besnard
Oct 10, 2012·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Dalian DingRichard Salvi
Apr 26, 2012·The Annals of Otology, Rhinology, and Laryngology·Jianfen Luo, Lei Xu
Oct 1, 2011·Journal of Zhejiang University. Science. B·Hong LiuHong Sun
Jun 3, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Ashley KitaLarry Hoffman

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